Large cell neuroendocrine carcinoma of the lung with a cystic appearance on computed tomography

被引：4
作者：
Tanaka K. [1 ,2 ,3 ]
Tsuboi M. [2 ]
Kato H. [2 ]
机构：
[1] Department of Surgery, Sapporo-Kosei General Hospital, Sapporo, Hokkaido
[2] First Department of Surgery, Tokyo Medical University, Tokyo
[3] Department of Surgery, Sapporo-Kosei General Hospital, Chuo-ku, Sapporo, Hokkaido 060-0033, Higashi 8-5
来源：
General Thoracic and Cardiovascular Surgery | 2006年 / 54卷 / 4期
关键词：
Computed tomography; Cystic tumor; Large cell neuroendocrine carcinoma; Lung;
D O I：
10.1007/BF02662475
中图分类号：
学科分类号：
摘要：
Almost all reported cases of large cell neuroendocrine carcinoma (LCNEC) of the lung are solid-type tumors. We encountered a rare case of LCNEC displaying a cystic shape. An abnormal cystic shadow was revealed on chest computed tomography in a 71-year-old man who underwent total gastrectomy due to gastric cancer 5 years earlier. The cystic lesion enlarged from 7 mm to 16 mm over 7 months, so surgery was performed for definitive diagnosis and therapy. Microscopy revealed rosette patterns, a high mitotic rate and a large area of necrosis. Neuroendocrine differentiation was confirmed on immunohistochemical examinations using chromogranin, synaptophysin and NCAM (CD56). Given these findings, LCNEC was diagnosed. This is the first report of LCNEC with a cystic shape. This case challenges preconceptions regarding the radiographic appearance of LCNEC.
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页码：174 / 177
页数：3
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