Second-Generation AntipsychoticsIs There Evidence for Sex Differences in Pharmacokinetic and Adverse Effect Profiles?

被引:0
作者
Wolfgang Aichhorn
Alexandra B. Whitworth
Elisabeth M. Weiss
Josef Marksteiner
机构
[1] Medical University Innsbruck,Department of General Psychiatry
来源
Drug Safety | 2006年 / 29卷
关键词
Clozapine; Risperidone; Olanzapine; Quetiapine; Sexual Dysfunction;
D O I
暂无
中图分类号
学科分类号
摘要
Six second-generation antipsychotics (SGAs), aripiprazole, clozapine, olanzapine, quetiapine, risperidone and ziprasidone, are currently US FDA approved. The aim of this review is to investigate whether sex differences exist for efficacy and adverse effects of these drugs.
引用
收藏
页码:587 / 598
页数:11
相关论文
共 331 条
[1]  
Leung A(2000)Sex differences in schizophrenia, a review of the literature Acta Psychiatr Scand Suppl 401 3-38
[2]  
Chue P(1983)Sex-related differences in clinical drug response: implications for women’s health J Am Med Womens Assoc 38 126-32
[3]  
Hamilton J(2005)Sex and racial differences in pharmacological response: where is the evidence? Pharmacogenetics, pharmacokinetics, and pharmacodynamics J Womens Health 14 19-29
[4]  
Parry B(2002)How important are gender differences in pharmacokinetics? Clin Pharmacokinet 41 329-42
[5]  
Anderson GD(1993)Mechanism of the cardiotoxic actions of terfenadine JAMA 269 1532-6
[6]  
Meibohm B(2002)Sex-based differences in the effect of digoxin for the treatment of heart failure N Engl J Med 347 1403-11
[7]  
Beierle I(2002)Clozapine, olanzapine, risperidone, and haloperidol in the treatment of patients with chronic schizophrenia and schizoaffective disorder Am J Psychiatry 159 255-62
[8]  
Derendorf H(1999)Effects of gender and age on plasma levels of clozapine and its metabolites: analyzed by critical statistics J Clin Psychiatry 60 36-40
[9]  
Woosley RL(2003)Therapeutic drug monitoring of olanzapine: the combined effect of age, gender, smoking, and comedication Ther Drug Monit 25 46-53
[10]  
Chen Y(2005)Effects of age and sex on olanzapine plasma concentrations J Clin Psychopharmacol 25 570-4