Changes in Chromatin Organization during Early Development and Carcinogenesis

被引：0
作者：
A. Hair
Y. Vassetzky
S. V. Razin
机构：
[1] The University of Manchester,Gene Expression Group, School of Biological Sciences
[2] Institut de Génétique Humaine,Russian Academy of Sciences
[3] CNRS UPR1142,Russian Academy of Sciences
[4] Kol'tsov Institute of Developmental Biology,undefined
[5] Institute of Gene Biology,undefined
来源：
Russian Journal of Developmental Biology | 2002年 / 33卷 / 2期
关键词：
nuclear matrix; DNA loop domains; development; cancer; chromatin;
D O I：
10.1023/A:1014916626493
中图分类号：
学科分类号：
摘要：
Similar changes in chromatin organization take place during development and carcinogenesis. The size of chromatin loop domains fixed on the nuclear skeleton (matrix) increased from 20 to approximately 200 kb. These changes are accompanied by an increased size of replicons and altered specificity of loop attachment to the nuclear matrix. During carcinogenesis, inverse changes in the chromatin structure are observed, neoplastic cells are dedifferentiated and return to the initial state. In this review, we consider new experimental data on organization of the DFNA loops and nuclear matrix in embryogenesis and carcinogenesis.
引用
收藏
页码：61 / 64
页数：3
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