The value of LGI1, Caspr2 and voltage-gated potassium channel antibodies in encephalitis

被引：0
作者：
Agnes van Sonderen
Mar Petit-Pedrol
Josep Dalmau
Maarten J. Titulaer
机构：
[1] Erasmus University Medical Center,Department of Neurology
[2] Haga Hospital,Department of Neurology
[3] Neuroimmunology Program,Department of Neurology
[4] Institut d'Investigació Biomèdica August Pi i Sunyer (IDIBAPS),undefined
[5] University of Barcelona,undefined
[6] Centro de Investigación Biomédica en Red (CIBER),undefined
[7] Hospital Clinic,undefined
[8] Institució Catalana de Recerca i Estudis Avançats (ICREA),undefined
[9] University of Pennsylvania,undefined
来源：
Nature Reviews Neurology | 2017年 / 13卷
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摘要：
Three groups of voltage-gated potassium channel (VGKC) antibody-positive patients should be distinguished: patients with antibodies against leucine-rich glioma-inactivated 1 (LGI1), patients with antibodies against contactin-associated protein-like 2 (Caspr2), and patients lacking both of these antibodiesPatients with anti-LGI1 antibodies usually present with typical limbic encephalitis, including alteration of memory and behaviour, spatial disorientation and several types of seizuresPatients with anti-Caspr2 antibodies present with various syndromes that involve the CNS and/or PNS, which mainly consist of cognitive decline, epilepsy and peripheral nerve hyperexcitabilityPatients with antibodies against LGI1 or Caspr2 usually respond well to immunotherapyThe clinical relevance of antibodies against the VGKC complex that lack reactivity against LGI1 and Caspr2 is uncertain; in patients with these antibodies, clinical assessment and ancillary tests prevail for the establishment of a diagnosis and formulation of treatment
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页码：290 / 301
页数：11
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