Cytotoxic effect of a polymer–copper(II) complex containing 2,2′-bipyridyl ligand on human lung cancer cells

被引：0
作者：
R. Senthil Kumar
V. S. Periasamy
C. Preethy Paul
A. Riyasdeen
S. Arunachalam
M. A. Akbarsha
机构：
[1] Ecole Polytechnique Fédérale de Lausanne (EPFL),Laboratory of Photomedicine
[2] Bharathidasan University,Department of Animal Science
[3] Bharathidasan University,Department of Chemistry
来源：
Medicinal Chemistry Research | 2011年 / 20卷
关键词：
Polymer–metal complex; Copper complex; Cytotoxicity; Apoptosis; Necrosis;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The cytotoxic activity of the polymer–copper(II) complex, [Cu(bpy)2(BPEI)]Cl2·4H2O (bpy = 2,2′-bipyridine, BPEI = branched polyethyleneimine) on NCI-H460 human lung cancer cells was determined adopting MTT assay and specific staining techniques. Many of the cultured NCI-H460 cancer cells treated with this complex suffered loss of viability and death mostly through apoptosis and/or necrosis as evidenced by the changes in the nuclear morphology and cytoplasmic features.
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页码：726 / 731
页数：5
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