Interaction of reactive astrocytes with type I collagen induces astrocytic scar formation through the integrin–N-cadherin pathway after spinal cord injury

被引：0
作者：
Masamitsu Hara
Kazu Kobayakawa
Yasuyuki Ohkawa
Hiromi Kumamaru
Kazuya Yokota
Takeyuki Saito
Ken Kijima
Shingo Yoshizaki
Katsumi Harimaya
Yasuharu Nakashima
Seiji Okada
机构：
[1] Graduate School of Medical Sciences,Department of Advanced Medical Initiatives
[2] Kyushu University,Department of Orthopaedic Surgery
[3] Graduate School of Medical Sciences,Division of Transcriptomics
[4] Kyushu University,undefined
[5] Medical Institute of Bioregulation,undefined
[6] Kyushu University,undefined
来源：
Nature Medicine | 2017年 / 23卷
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摘要：
In a mouse model of spinal cord injury, reactive astrogliosis is found to be context dependent and reversible. Blockade of type I collagen–reactive astrocyte interactions prevents astrocyte scar formation and facilitates functional recovery after injury.
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页码：818 / 828
页数：10
相关论文
共 112 条
[1]  
McDonald JW(2002)Spinal-cord injury Lancet 359 417-425
[2]  
Sadowsky C(2006)Conditional ablation of Stat3 or Socs3 discloses a dual role for reactive astrocytes after spinal cord injury Nat. Med. 12 829-834
[3]  
Okada S(2004)Regeneration beyond the glial scar Nat. Rev. Neurosci. 5 146-156
[4]  
Silver J(2012)Reactive astrogliosis after spinal cord injury—beneficial and detrimental effects Mol. Neurobiol. 46 251-264
[5]  
Miller JH(1997)Reactive astrocytes: cellular and molecular cues to biological function Trends Neurosci. 20 570-577
[6]  
Karimi-Abdolrezaee S(2004)Gradual loss of myelin and formation of an astrocytic scar during Wallerian degeneration in the human spinal cord Brain 127 34-44
[7]  
Billakanti R(2016)Astrocyte scar formation aids central nervous system axon regeneration Nature 532 195-200
[8]  
Ridet JL(2016)Regeneration: not everything is scary about a glial scar Nature 532 182-183
[9]  
Malhotra SK(1952)Inhibition of formation of a glial barrier as a means of permitting a peripheral nerve to grow into the brain J. Comp. Neurol. 96 359-369
[10]  
Privat A(1954)Return of spinal cord function in mammals after transecting lesions Ann. NY Acad. Sci. 58 564-569
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