Depression, Alcohol Use and Adherence to Antiretroviral Therapy in Sub-Saharan Africa: A Systematic Review

被引：0
作者：
Etheldreda Nakimuli-Mpungu
Judith K. Bass
Pierre Alexandre
Edward J. Mills
Seggane Musisi
Malathi Ram
Elly Katabira
Jean B. Nachega
机构：
[1] Johns Hopkins Bloomberg School of Public Health,Department of Mental Health
[2] Makerere University College of Health Sciences,Department of Psychiatry
[3] University British of Columbia,Centre for Excellence in AIDS Care
[4] Johns Hopkins Bloomberg School of Public Health,Department of International Health
[5] Johns Hopkins Bloomberg School of Public Health,Department of Epidemiology
[6] Makerere University College of Health Sciences,Department of Internal Medicine
[7] Stellenbosch University,Department of Medicine and Centre for Infectious Diseases, Faculty of Health Sciences
来源：
AIDS and Behavior | 2012年 / 16卷
关键词：
Depression; Alcohol; HIV; ART adherence; Systematic review;
D O I：
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学科分类号：
摘要：
This study evaluated estimates of depression symptoms, major depression, alcohol use or disorders and their association with ART adherence in sub-Saharan Africa. Studies published between January 1, 2006 and July 31, 2011 that documented rates of these mental health problems were identified through electronic databases. A pooled analysis of 23 studies reporting rates of depression symptoms and six studies reporting rates of major depression indicated a pooled estimate of 31.2% (95% CI 25.5–38.2%, Tau2 = 0.23) and 18% (95% CI 12.3–25.8%, Tau2 = 0.19) respectively. Few studies reported rates of alcohol use or disorders, and so we did not pool their estimates. Likelihood of achieving good adherence was 55% lower among those with depression symptoms compared to those without (pooled OR = 0.45 (95% CI 0.31–0.66, Tau2 = 0.20, P value = 0.000). Interventions to improve mental health of HIV-positive individuals and to support adherence are desperately needed in sub-Saharan Africa.
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页码：2101 / 2118
页数：17
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[1]  
Jahn A(2008)Population-level effect of HIV on adult mortality and early evidence of reversal after introduction of antiretroviral therapy in Malawi Lancet 371 1603-1611
[2]  
Floyd S(2009)Steep declines in population-level AIDS mortality following the introduction of antiretroviral therapy in Addis Ababa, Ethiopia AIDS 23 511-518
[3]  
Crampin AC(2008)Not all missed doses are the same: sustained NNRTI treatment interruptions predict HIV rebound at low-to-moderate adherence levels PLoS One 3 e2783-1249
[4]  
Reniers G(2005)No room for complacency about adherence to antiretroviral therapy in sub-Saharan Africa AIDS 19 1243-S278
[5]  
Araya T(2006)Adherence to HAART: a systematic review of developed and developing nation patient-reported barriers and facilitators PLoS Med 3 e438-510
[6]  
Davey G(2008)Preventing HIV antiretroviral resistance through better monitoring of treatment adherence J Infect Dis 197 S272-S25
[7]  
Parienti JJ(2009)Social position, gender role, and treatment adherence among Colombian women living with HIV/AIDS: social determinants of health approach Rev Panam Salud Publica 26 502-232
[8]  
Das-Douglas M(2004)Medication adherence in HIV-infected adults: effect of patient age, cognitive status, and substance abuse AIDS 18 S19-121
[9]  
Massari V(2007)Depression, social support and adherence to highly active antiretroviral therapy in people living with HIV/AIDS Sex Health 4 227-S148
[10]  
Gill CJ(2006)Depression and neuro-cognitive performance in individuals with HIV/AIDS: 2-year follow-up HIV Med 7 112-129
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