Association of HLA-DRB1, DQB1 alleles with chronic urticaria

被引：0
作者：
Chen Jing
Tan Zhijian
Li Liawen
Xiong Ping
机构：
[1] Huangzhong University of Science and Technology,Department of Dermatology, Union Hospital, Tongji Medical College
来源：
Current Medical Science | 2005年 / 25卷 / 3期
关键词：
urticaria, chronic; genes, MHC class II; polymerase chain reaction-sequence specific primer;
D O I：
10.1007/BF02828166
中图分类号：
学科分类号：
摘要：
In order to investigate the association of genotypes of HLA-DRB1 and HLA-DQB1 alleles with the genetic susceptibility of chronic urticaria (CU), genotypes of HLA-DRB1 and HLA-DQB1 genes were detected by polymerase chain reactions with sequence-specific primers (PCR-SSP) in 42 patients with CU (19 men and 23 women, mean age 30.67±12.45 y old as well as 193 racially matched healthy persons in ethnic Han from Hubei provinece. Gene frequencies of HLA-DRB1* 12. * 0901 (RR=3.11, χ2=7.579,P=0.006; RR=2.47, χ2=5.684,P=0.017) were significantly increased in CU patients as compared with that in healthy people. Gene frequencies of HLA-DQB1 * 05 (RR=0.26, χ2=6.683,P=0.01) were significantly decreased in CU patients. It was suggested that CU was found strongly associated with HLA-DRB1 * 12, * 0901 and HLA-DQB1 * 05, the former might be the genetic markers for susceptibility to CU, but the latter might play a resistive role.
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页码：354 / 356
页数：2
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