neo-Clerodane diterpenoids from Salvia dugesii and their bioactive studies

被引：24
|
作者：
Gang X. [1 ]
Fang Z. [2 ]
Xian-Wen Y. [3 ]
Juan Z. [2 ]
Li-Xin Y. [1 ]
Shen X.-L. [2 ]
Hu Y.-J. [2 ]
Zhao Q.-S. [1 ]
机构：
[1] State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming
[2] Tropical Medicine Institute, Guangzhou University of Chinese Medicine, Guangzhou
[3] Key Laboratory of Marine Bio-resources Sustainable Utilization, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou
来源：
Natural Products and Bioprospecting | 2011年 / 1卷 / 2期
关键词：
antivirus; dugesins; neo-clerodane diterpenoids; Salvia dugesii;
D O I：
10.1007/s13659-011-0016-6
中图分类号：
学科分类号：
摘要：
Salvia dugesii is an invasive plant in Yunnan, China. To tentatively explore its utilization, a systematic phytochemical investigation was carried out on this plant, which led to the isolation of five new neo-clerodane diterpenoids, dugesins C–G (1–5), together with six known ones. Their structures were determined by comprehensive NMR and MS spectroscopic analysis. It was noteworthy that the eleven isolates, composed of five different carbocyclic systems derived from the neo-clerodane diterpenoid skeleton, were reported from the same plant for the first time. The anti-feedantial, cytotoxic, and antiviral activities of the isolates were evaluated. Dugesin F (4) was tested to be a non-toxic antiviral compound against influenza virus FM1.[Figure not available: see fulltext.]. © 2011, The Author(s).
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页码：81 / 86
页数：5
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