Constitutively decreased TGFBR1 allelic expression is a common finding in colorectal cancer and is associated with three TGFBR1 SNPs

被引:0
作者
Boris Pasche
Kari B Wisinski
Maureen Sadim
Virginia Kaklamani
Michael J Pennison
Qinghua Zeng
Naresh Bellam
Jacquelyn Zimmerman
Nengjun Yi
Kui Zhang
John Baron
Daniel O Stram
M Geoffrey Hayes
机构
[1] The University of Alabama at Birmingham and UAB Comprehensive Cancer Center,Division of Hematology/Oncology
[2] University of Wisconsin School of Medicine and Public Health,Section of Hematology/Oncology
[3] Feinberg School of Medicine,Cancer Genetics Program, Division of Hematology/Oncology, Department of Medicine
[4] Northwestern University,Section of Statistical Genetics, Department of Biostatistics
[5] School of Public Health,Departments of Medicine and Community and of Community and Family Medicine
[6] The University of Alabama at Birmingham,Department of Preventive Medicine
[7] Dartmouth,Division of Endocrinology, Metabolism, and Molecular Medicine, Department of Medicine
[8] Keck School of Medicine,Center for Genetic Medicine
[9] University of Southern California,Department of Anthropology
[10] Feinberg School of Medicine,undefined
[11] Northwestern University,undefined
[12] Feinberg School of Medicine,undefined
[13] Northwestern University,undefined
[14] Northwestern University,undefined
来源
Journal of Experimental & Clinical Cancer Research | / 29卷
关键词
Colorectal Cancer; Familial Adenomatous Polyposis; Lynch Syndrome; Lymphoblastoid Cell Line; Colorectal Cancer Risk;
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  • [11] Di Bernardo MC(2007)Lack of an Association between the TGFBR1*6A Variant and Colorectal Cancer Risk Clinical Cancer Research 13 3748-3752
  • [12] Lubbe S(2009)Tgfbr1 Haploinsufficiency Is a Potent Modifier of Colorectal Cancer Development Cancer Res 69 678-686
  • [13] Broderick P(1995)Inactivation of the type II TGF-beta receptor in colon cancer cells with microsatellite instability Science 268 1336-1338
  • [14] Carvajal-Carmona L(2008)Germline allele-specific expression of TGFBR1 confers an increased risk of colorectal cancer Science 321 1361-1365
  • [15] Pittman AM(2009)Infrequent Detection of Germline Allele-Specific expression of TGFBR1 in Lymphoblasts and Tissues of Colon Cancer Patients Cancer Res 69 4959-4961
  • [16] Webb E(2008)Variants of the adiponectin (ADIPOQ) and adiponectin receptor 1 (ADIPOR1) genes and colorectal cancer risk JAMA 300 1523-1531
  • [17] Howarth K(2007)Somatic acquisition of TGFBR1*6A by epithelial and stromal cells during head and neck and colon cancer development Human Molecular Genetics 16 3128-3135
  • [18] Rowan A(2009)Genomic Alterations in Tumor Stroma Cancer Res 69 6759-6764
  • [19] Tenesa A(2004)TGF-{beta} Signaling in Fibroblasts Modulates the Oncogenic Potential of Adjacent Epithelia Science 303 848-851
  • [20] Dunlop MG(undefined)undefined undefined undefined undefined-undefined