MYL6B, a myosin light chain, promotes MDM2-mediated p53 degradation and drives HCC development

被引:0
作者
Xingwang Xie
Xueyan Wang
Weijia Liao
Ran Fei
Nan Wu
Xu Cong
Qian Chen
Lai Wei
Yu Wang
Hongsong Chen
机构
[1] Peking University Hepatology Institute,Peking University People’s Hospital
[2] Beijing Key Laboratory of Hepatitis C and Immunotherapy for Liver Disease,Laboratory of Hepatobiliary and Pancreatic Surgery
[3] Chinese Center for Disease Control and Prevention,undefined
[4] Affiliated Hospital of Guilin Medical University,undefined
来源
Journal of Experimental & Clinical Cancer Research | / 37卷
关键词
Non-muscle Myosin II (NMII); MDM2-mediated Ubiquitination; Clone Formation Assay; Apoptosis Levels; TCGA Cohort;
D O I
暂无
中图分类号
学科分类号
摘要
引用
收藏
相关论文
共 172 条
[1]  
Levine AJ(2009)The first 30 years of p53: growing ever more complex Nat Rev Cancer 9 749-758
[2]  
Oren M(2016)Whole-genome mutational landscape and characterization of noncoding and structural mutations in liver cancer Nat Genet 48 500-509
[3]  
Fujimoto A(1997)Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53 FEBS Lett 420 25-27
[4]  
Furuta M(1995)Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53 Nature 378 203-206
[5]  
Totoki Y(2012)The many faces of MDM2 binding partners Genes & cancer 3 226-239
[6]  
Tsunoda T(2004)A dynamic role of HAUSP in the p53-Mdm2 pathway Mol Cell 13 879-886
[7]  
Kato M(1998)The Ink4a tumor suppressor gene product, p19Arf, interacts with MDM2 and neutralizes MDM2's inhibition of p53 Cell 92 713-723
[8]  
Shiraishi Y(2002)Cyclin G recruits PP2A to dephosphorylate Mdm2 Mol Cell 9 761-771
[9]  
Tanaka H(2013)A genomic toolkit to investigate kinesin and myosin motor function in cells Nat Cell Biol 15 325-334
[10]  
Taniguchi H(2015)Non-muscle myosin II in disease: mechanisms and therapeutic opportunities Dis Model Mech 8 1495-1515