TRF2 binds branched DNA to safeguard telomere integrity

被引：0
|
作者：
Isabelle Schmutz
Leonid Timashev
Wei Xie
Dinshaw J Patel
Titia de Lange
机构：
[1] Laboratory for Cell Biology and Genetics,
[2] The Rockefeller University,undefined
[3] Structural Biology Program,undefined
[4] Memorial Sloan-Kettering Cancer Center,undefined
来源：
Nature Structural & Molecular Biology | 2017年 / 24卷
关键词：
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Functional analysis of TRF2-RuvC chimeras establishes that binding of the TRF2 basic domain to branched-DNA structures of the t-loop is responsible for telomere protection in mouse and human cells.
引用
收藏
页码：734 / 742
页数：8
相关论文
共 50 条
  • [1] TRF2 binds branched DNA to safeguard telomere integrity
    Schmutz, Isabelle
    Timashev, Leonid
    Xie, Wei
    Patel, Dinshaw J.
    de lange, Titia
    NATURE STRUCTURAL & MOLECULAR BIOLOGY, 2017, 24 (09) : 734 - +
  • [2] Modulating TRF2 expression preserves telomere integrity and prevents DNA DSBs, during aging
    Bergeron, L.
    Lebleu, A.
    Court, E.
    Busuttil, V.
    Botto, J.
    Domloge, N.
    JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2012, 132 : S82 - S82
  • [3] TIN2 binds TRF1 and TRF2 simultaneously and stabilizes the TRF2 complex on telomeres
    Ye, JZS
    Donigian, JR
    van Overbeek, M
    Loayza, D
    Luo, Y
    Krutchinsky, AN
    Chait, BT
    de Lange, T
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2004, 279 (45) : 47264 - 47271
  • [4] TRF2 binding to telomere nucleosomal arrays
    Baker, Asmaa M.
    Khan, Sheik J.
    Fletcher, Terace M.
    FASEB JOURNAL, 2007, 21 (06): : A1036 - A1037
  • [5] Telomere-binding protein TRF2 binds to and stimulates the Werner and Bloom syndrome helicases
    Opresko, PL
    von Kobbe, C
    Laine, JP
    Harrigan, J
    Hickson, ID
    Bohr, VA
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (43) : 41110 - 41119
  • [6] Control of human telomere length by TRF1 and TRF2
    Smogorzewska, A
    Van Steensel, B
    Bianchi, A
    Oelmann, S
    Schaefer, MR
    Schnapp, G
    De Lange, T
    MOLECULAR AND CELLULAR BIOLOGY, 2000, 20 (05) : 1659 - 1668
  • [7] Gemcitabine causes telomere shortening by stabilizing TRF2
    Su Chih-Hao
    Tsai Ying-Chieh
    Lee Wei-Ping
    CANCER RESEARCH, 2012, 72
  • [8] Telomere Shortening, Telomere Protein TRF1 and TRF2 Activation, and DNA Damage Response Impairement during Bronchial Carcinogenesis
    Lantuejoul, S.
    Raynaud, C.
    Gazzeri, S.
    Moro-Sibilot, D.
    Salameire, D.
    Soria, J. C.
    Brambilla, E.
    LABORATORY INVESTIGATION, 2009, 89 : 355A - 356A
  • [9] Gemcitabine causes telomere attrition by stabilizing TRF2
    Su, Chih-Hao
    Chu, Wei-Chih
    Lan, Keng-Hsin
    Li, Chung-Pin
    Chao, Yee
    Lin, Han-Chieh
    Lee, Shou-Dong
    Tsai, Ying-Chieh
    Lee, Wei-Ping
    EUROPEAN JOURNAL OF CANCER, 2012, 48 (18) : 3465 - 3474
  • [10] Telomere shortening and expression of TRF1 and TRF2 in uterine leiomyoma
    Oh, Bong-Kyeong
    Choi, Yoojung
    Choi, Joong Sub
    MOLECULAR MEDICINE REPORTS, 2021, 24 (02)
12345