Middle Ear “Adenoma”: a Neuroendocrine Tumor with Predominant L Cell Differentiation

被引：0

作者：

Sylvia L. Asa

Knarik Arkun

Arthur S. Tischler

Adnan Qamar

Fang-Ming Deng

Bayardo Perez-Ordonez

Ilan Weinreb

Justin A. Bishop

Bruce M. Wenig

Ozgur Mete

机构：

[1] University Hospitals Cleveland Medical Center,Department of Pathology

[2] Case Western Reserve University,Department of Pathology and Laboratory Medicine

[3] Tufts Medical Center,Department of Pathology

[4] NYU,Department of Pathology

[5] University Health Network,Department of Pathology

[6] University of Toronto,Department of Pathology

[7] University of Texas Southwestern Medical Center,undefined

[8] Moffitt Cancer Center,undefined

来源：

Endocrine Pathology | 2021年 / 32卷

关键词：

Middle ear adenoma; Neuroendocrine tumor; L cell;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

This morphological and immunohistochemical study demonstrates that tumors currently known as “middle ear adenomas” are truly well-differentiated epithelial neuroendocrine tumors (NETs) composed of cells comparable to normal intestinal L cells, and therefore, these tumors resemble hindgut NETs. These tumors show consistent expression of glucagon, pancreatic polypeptide, PYY, and the transcription factor SATB2, as well as generic neuroendocrine markers and keratins. The same L cell markers are expressed by cells within the normal middle ear epithelium. These markers define a valuable immunohistochemical profile that can be used for differential diagnosis of middle ear neoplasms, particularly in distinguishing epithelial NETs from paragangliomas. The discovery of neuroendocrine cells expressing the same markers in non-neoplastic middle ear mucosa opens new areas of investigation into the physiology of the normal middle ear and the pathophysiology of middle ear disorders.

引用

页码：433 / 441

页数：8

共 177 条

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