Crystal-Storing Histiocytosis: Report of a Case, Review of the Literature (80 Cases) and a Proposed Classification

被引：103
作者：
Dogan S. [1 ]
Barnes L. [2 ]
Cruz-Vetrano W.P. [3 ]
机构：
[1] Department of Pathology, Memorial Sloan-Kettering Cancer Center, New York, NY 10065
[2] Emeritus Professor of Pathology, University of Pittsburgh Medical Center, Presbyterian Hospital, Pittsburgh, PA 15213
[3] Laboratory Services, Altoona Regional Health System, Altoona
来源：
Head and Neck Pathology | 2012年 / 6卷 / 1期
关键词：
Crystal-storing histiocytosis; Histiocytes; Immunoglobulin crystals; Intracellular crystals;
D O I：
10.1007/s12105-011-0326-3
中图分类号：
学科分类号：
摘要：
We report a case of crystal storing histiocytosis (CSH) of the upper lip and cheek in a 51-year-old woman and review the clinicopathologic features of 80 cases in the literature. These occurred in 41 men and 39 women with a respective mean age of 59 and 61 years (range 17-81 years). Forty-six patients (58%) had localized CSH, and, of these, 16 (35%) occurred in the head and neck, with the most common site being the eye/orbit. The remaining 34 patients (42%) had generalized CSH primarily involving bone marrow, liver, lymph nodes, spleen and/or kidney. Regardless of whether the CSH was localized or generalized, the vast majority of patients (90%) had an underlying lymphoproliferative or plasma cell disorder, especially multiple myeloma, lymphoplasmacytic lymphoma, or monoclonal gammopathy of undetermined significance. In 7 cases (8.8%), the CSH was associated with a variety of benign disorders, often with an inflammatory background, and no evidence of a clonal lymphoproliferative or plasma cell disorder. Treatment and prognosis varied according to the underlying disease. A classification of CSH based on etiology and/or associated disease and chemical composition of the crystal is proposed, rare non-immunoglobulin variants of CSH are discussed, and a differential diagnosis of other potentially confusing lesions is provided. © 2012 Springer Science+Business Media, LLC.
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页码：111 / 120
页数：9
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