Inflammasomes and Anti-Viral Immunity

被引:0
|
作者
Vijay A. K. Rathinam
Katherine A. Fitzgerald
机构
[1] University of Massachusetts Medical School,Division of Infectious Diseases and Immunology, Department of Medicine
来源
Journal of Clinical Immunology | 2010年 / 30卷
关键词
Inflammasomes; interleukin; virus;
D O I
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学科分类号
摘要
Type I Interferons are the hallmark cytokines deployed during infection to combat invading viruses. However, inflammatory cytokines such as Interleukin (IL)-1β and IL-18 also play important roles in anti-viral defenses. The activity of IL-1β and IL18 are regulated at the level of expression, processing, and secretion. Several classes of innate immune receptors control the expression of these cytokines, which must then be proteolytically processed via caspase-1. In this review, we provide an overview of how caspase-1-activating inflammasomes participate during viral infections and their role in regulating anti-viral immunity.
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页码:632 / 637
页数:5
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