The recent development and applications of fluidic channels by 3D printing

被引：0
作者：
Yufeng Zhou
机构：
[1] Nanyang Technological University,Singapore Centre for 3D Printing (SC3DP), School of Mechanical and Aerospace Engineering
来源：
Journal of Biomedical Science | / 24卷
关键词：
Fluidic channel; Lab-on-a-chip; 3D printing; Diagnosis; Tissue engineering; Reactionware;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The technology of “Lab-on-a-Chip” allows the synthesis and analysis of chemicals and biological substance within a portable or handheld device. The 3D printed structures enable precise control of various geometries. The combination of these two technologies in recent years makes a significant progress. The current approaches of 3D printing, such as stereolithography, polyjet, and fused deposition modeling, are introduced. Their manufacture specifications, such as surface roughness, resolution, replication fidelity, cost, and fabrication time, are compared with each other. Finally, novel application of 3D printed channel in biology are reviewed, including pathogenic bacteria detection using magnetic nanoparticle clusters in a helical microchannel, cell stimulation by 3D chemical gradients, perfused functional vascular channels, 3D tissue construct, organ-on-a-chip, and miniaturized fluidic “reactionware” devices for chemical syntheses. Overall, the 3D printed fluidic chip is becoming a powerful tool in the both medical and chemical industries.
引用
收藏
相关论文
共 643 条
  • [11] Whitesides GM(2014)Modeling of cancer metastasis and drug resistance via biomimetic nano-cilia and microfluidics Biomaterials 35 1562-954
  • [12] Whitesides GM(2010)A microfluidic hepatic coculture platform for cell-based drug metabolism studies Biochem Pharmacol 79 1036-581
  • [13] Verpoorte E(2007)Serial immunoassays in parallel on a microfluidic chip for monitoring hormone secretion from living cells Anal Chem 79 947-754
  • [14] Benavente-Babace A(2009)Integrated microfluidic systems for high-performance genetic analysis Trends Biotechnol 27 572-1668
  • [15] Gallego-Pérez D(2011)From 3D cell culture to organs-on-chips Trends Cell Biol 21 745-746
  • [16] Hansford DJ(2010)Reconstituting organ-level lung functions on a chip Science 328 1662-189
  • [17] Arana S(2008)An integrated microfluidic system for long-term perfusion culture and on-line monitoring of intestinal tissue models Lab Chip 8 741-418
  • [18] Pérez-Lorenzo E(2014)The present and future role of microfluidics in biomedical research Nature 507 181-410
  • [19] Mujika M(2012)In vitro modeling of the microvascular occlusion and thrombosis that occur in hematologic diseases using microfluidic technology J Clin Invest 122 408-2115
  • [20] Holmes D(2008)Nano-aquarium for dynamic observation of living cells fabricated by femtosecond laser direct writing of photostructurable glass Biomed Microdevices 10 403-4984
12345678910