Case studies of two related Chinese patients with Carney complex presenting with extensive cardiac myxomas and PRKAR1A gene mutation of c.491_492delTG

被引：0

作者：

Hongwei Guo

Jianping Xu

Hui Xiong

Shengshou Hu

机构：

[1] Chinese Academy of Medical Sciences and Peking Union Medical College,State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases

来源：

World Journal of Surgical Oncology | / 13卷

关键词：

Carney complex; PRKAR1A; Mutation; Myxomas;

D O I：

暂无

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学科分类号：

摘要：

Carney complex is an autosomal dominant disease that is clinically characterized by cardiac myxomas, spotty skin pigmentation, and endocrine overactivity. Carney complex is most commonly caused by mutations in the PRKAR1A gene on chromosome 17q22-24. Currently, there are at least 117 pathogenic mutations in PRKAR1A that have been identified. Herein, we report on two cases of Carney complex in related Chinese patients with a c.491_492delTG mutation that presented with multiple and extensive cardiac myxomas and skin pigmentation.

引用

共 23 条

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[8] Kirschner LS(undefined)undefined undefined undefined undefined-undefined
[9] Carney JA(undefined)undefined undefined undefined undefined-undefined
[10] Sandrini F(undefined)undefined undefined undefined undefined-undefined

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