Insights and limits of translational research in critical care medicine

被引：0
作者：
Frédéric Pène
Hafid Ait-Oufella
Fabio Silvio Taccone
Guillaume Monneret
Tarek Sharshar
Fabienne Tamion
Jean-Paul Mira
机构：
[1] Hôpital Cochin,Service de Réanimation Médicale
[2] Assistance Publique-Hôpitaux de Paris,Faculté de Médecine
[3] Université Paris Descartes,Service de Réanimation Médicale
[4] Hôpital Saint-Antoine,Faculté de Médecine
[5] Assistance Publique-Hôpitaux de Paris,Département de Soins Intensifs, Hôpital Erasme
[6] Université Pierre-et-Marie-Curie,Laboratoire d’Immunologie Cellulaire
[7] Université Libre de Bruxelles,Institut des Sciences Pharmaceutiques et Biologiques
[8] Hôpital Edouard Herriot,Service de Réanimation
[9] Hospices Civils de Lyon,Service de Réanimation Médicale
[10] Université Lyon I,Faculté de Médecine
[11] Hôpital Raymond Poincaré,undefined
[12] Assistance Publique-Hôpitaux de Paris,undefined
[13] 104 Boulevard Raymond Poincaré,undefined
[14] Université de Versailles-Saint Quentin en Yvelines,undefined
[15] Hôpital Charles Nicolle,undefined
[16] CHU Rouen,undefined
[17] Institut de Recherche et Innovation Biomédicale (IRIB),undefined
来源：
Annals of Intensive Care | / 5卷
关键词：
Critical care medicine; Translational research; Sepsis; Microcirculation; Critical illness-related neuromyopathy;
D O I：
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摘要：
Experimental research has always been the cornerstone of pathophysiological and therapeutic advances in critical care medicine, where clinical observations and basic research mutually fed each other in a so-called translational approach. The objective of this review is to address the different aspects of translational research in the field of critical care medicine. We herein highlighted some demonstrative examples including the animal-to-human approach to study host-pathogen interactions, the human-to-animal approach for sepsis-induced immunosuppression, the still restrictive human approach to study critical illness-related neuromyopathy, and the technological developments to assess the microcirculatory changes in critically ill patients. These examples not only emphasize how translational research resulted in major improvements in the comprehension of the pathophysiology of severe clinical conditions and offered promising perspectives in critical care medicine but also point out the obstacles to translate such achievements into clinical practice.
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