Inhibition of the AURKA/YAP1 axis is a promising therapeutic option for overcoming cetuximab resistance in colorectal cancer stem cells

被引:0
作者
Anxo Rio-Vilariño
Aiora Cenigaonandia-Campillo
Ana García-Bautista
Pedro A. Mateos-Gómez
Marina I. Schlaepfer
Laura del Puerto-Nevado
Oscar Aguilera
Laura García-García
Carlos Galeano
Irene de Miguel
Juana Serrano-López
Natalia Baños
María Jesús Fernández-Aceñero
Juan Carlos Lacal
Enzo Medico
Jesús García-Foncillas
Arancha Cebrián
机构
[1] Instituto de Investigación Sanitaria Fundación Jiménez Díaz,Translational Oncology Division, Oncohealth Institute
[2] Fundación Jiménez University Hospital (IIS-FJD,Biochemistry and Molecular Biology Unit, Department of System Biology, School of Medicine and Health Sciences
[3] UAM),Pathology Department
[4] University of Alcalá. Alcalá de Henares,Experimental Hematology Lab
[5] IIS-Fundación Jiménez Diaz-UAM,Preclinical program START Madrid
[6] IIS-Fundación Jimenez Díaz,FJD
[7] UAM,Department of Pathology, Hospital Clínico San Carlos
[8] Hospital Fundación Jiménez Díaz-UAM,Instituto de Investigaciones Biomédicas
[9] Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC),Instituto de Investigación Sanitaria Hospital La Paz
[10] CSIC/UAM,Department of Oncology
[11] IDIPAZ,Candiolo Cancer Institute
[12] Università degli Studi di Torino,undefined
[13] FPO-IRCCS,undefined
来源
British Journal of Cancer | 2024年 / 130卷
关键词
D O I
暂无
中图分类号
学科分类号
摘要
引用
收藏
页码:1402 / 1413
页数:11
相关论文
共 225 条
[1]  
Kekelidze M(2013)Colorectal cancer: current imaging methods and future perspectives for the diagnosis, staging and therapeutic response evaluation World J Gastroenterol 19 8502-14
[2]  
D’Errico L(2005)Cetuximab: an epidermal growth factor receptor monoclonal antibody for the treatment of colorectal cancer Clin Ther 27 684-94
[3]  
Pansini M(2013)Association of the epithelial-to-mesenchymal transition phenotype with responsiveness to the p21-activated kinase inhibitor, PF-3758309, in colon cancer models Front Pharm 4 35-712
[4]  
Tyndall A(2016)CD133+CD24lo defines a 5-Fluorouracil-resistant colon cancer stem cell-like phenotype Oncotarget 7 78698-51
[5]  
Hohmann J(2019)Sonic hedgehog pathway activation is associated with cetuximab resistance and EPHB3 receptor induction in colorectal cancer Theranostics 9 2235-64
[6]  
Wong SF(2017)Rationally co-targeting divergent pathways in KRAS wild-type colorectal cancers by CANscript technology reveals tumor dependence on Notch and Erbb2 Sci Rep 7 357-82
[7]  
Pitts TM(2015)Significant association of oncogene YAP1 with poor prognosis and cetuximab resistance in colorectal cancer patients Clin Cancer Res 21 2171-12
[8]  
Kulikowski GN(2018)Inhibition of YAP reverses primary resistance to EGFR inhibitors in colorectal cancer cells Oncol Rep 40 1601-10
[9]  
Tan AC(2021)ABHD5 inhibits YAP-induced c-Met overexpression and colon cancer cell stemness via suppressing YAP methylation Nat Commun 12 1-25
[10]  
Murray BW(2021)Effects of YAP1 and SFRP2 overexpression on the biological behavior of colorectal cancer cells and their molecular mechanisms J Gastrointest Oncol 12 414-75