The technological transformation of patient-driven human immunology research

被引：0
作者：
Helen C. Su
机构：
[1] National Institute of Allergy and Infectious Diseases,
[2] National Institutes of Health,undefined
来源：
Immunologic Research | 2009年 / 43卷
关键词：
Autoimmune lymphoproliferative syndrome (ALPS); Caspase-8 deficiency state (CEDS); NRAS; Small interfering RNA (siRNA); Next generation sequencing;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
New scientific technologies applied to patients with rare diseases are facilitating discoveries about how the human immune system is regulated at the molecular level. Studies of patients with autoimmune lymphoproliferative syndrome (ALPS) or caspase-8 deficiency state (CEDS) demonstrated the ability of gene expression microarray analyses and small interfering RNAs (siRNA) to establish the physiologically important roles of NRAS, caspase-10, and caspase-8 for normal lymphocyte apoptosis and activation. The advent of genomics technologies such as next generation sequencing will complement these and more traditional approaches. These advances are anticipated to accelerate the pace of new discoveries in patients with immunological disorders.
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页码：167 / 171
页数：4
相关论文
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