Changes in NMDA receptor subunit gene expression in the rat brain following withdrawal from forced long-term ethanol intake

被引：0

作者：

M.B. Darstein

G.B. Landwehrmeyer

T.J. Feuerstein

机构：

[1] Sektion Klinische Neuropharmakologie der Neurologischen Universitätsklinik,

[2] Neurozentrum,undefined

[3] Breisacher Strasse 64,undefined

[4] D-79106 Freiburg,undefined

[5] Germany,undefined

来源：

Naunyn-Schmiedeberg's Archives of Pharmacology | 2000年 / 361卷

关键词：

Ethanol Alcoholism NMDA receptor subunits Splice variants mRNA In situ hybridization histochemistry;

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摘要：

Changes in mRNA levels of N-methyl-d-aspartate receptor (NR) subunits were studied in a rat model of withdrawal from forced ethanol ingestion over a period of 8 days. In part, this model may reflect the epsilon-type of human alcoholism according to Jellinek (College University Press, New Haven; 1972). The epsilon-type is characterized by dipsomania over a period of several days, recurring every few months and often followed by ethanol-induced seizures. Seizures may be modulated by an increased glutamatergic neurotransmission to excitatory or inhibitory neurons on the basis of a changed gene expression of NR subunits. This hypothesis promoted the present study.

引用

页码：206 / 213

页数：7