Efferocytosis Modulates Arginase-1 and Tyrosine Kinase Mer Expression in GM-CSF-Differentiated Human Macrophages

被引：0

作者：

L. V. Sakhno

E. Ya. Shevela

M. A. Tikhonova

A. A. Maksimova

T. V. Tyrinova

A. A. Ostanin

E. R. Chernykh

机构：

[1] Research Institute of Fundamental and Clinical Immunology,

来源：

Bulletin of Experimental Biology and Medicine | 2021年 / 170卷

关键词：

human macrophages; efferocytosis; arginase-1; tyrosine kinase Mer;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

We studied the expression of arginase-1 (Arg1) and tyrosine kinase Mer (MerTK) in GMCSF-differentiated human macrophage populations М0, М1(IFNγ), М2а(IL-4), and М2(low serum) generated under conditions of growth/serum factor deficiency. The maximum relative content of Arg1+ and MerTK+ cells was found in М2 macrophage populations: М2а(IL-4) and М2(low serum). As the uptake of apoptotic cells is the key mechanism of M2 polarization during M2(low serum) generation, we performed a special series of experiments and showed that incubation with allogeneic apoptotic neutrophils significantly increased the percentages of CD206+ macrophages co-expressing Arg1 and MerTK.

引用

页码：778 / 781

页数：3

共 15 条

[1] Efferocytosis Modulates Arginase-1 and Tyrosine Kinase Mer Expression in GM-CSF-Differentiated Human Macrophages
Sakhno, L., V
Shevela, E. Ya
Tikhonova, M. A.
Maksimova, A. A.
Tyrinova, T., V
Ostanin, A. A.
Chernykh, E. R.
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE, 2021, 170 (06) : 778 - 781
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IMMUNOLOGY LETTERS, 2024, 265 : 23 - 30
[3] Yeast (Saccharomyces cerevisiae) Polarizes Both M-CSF- and GM-CSF-Differentiated Macrophages Toward an M1-Like Phenotype
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[6] GM-CSF MODULATES EXPRESSION OF TNF MESSENGER-RNA IN HUMAN MACROPHAGES
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LEHN, M
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[7] Distinct role of FoxO1 in M-CSF- and GM-CSF-differentiated macrophages contributes LPS-mediated IL-10: implication in hyperglycemia
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[8] Human protein S inhibits the uptake of AcLDL and expression of SR-A through Mer receptor tyrosine kinase in human macrophages
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[9] An Engineered Human Fc variant With Exquisite Selectivity for FcγRIIIaV158 Reveals That Ligation of FcγRIIIa Mediates Potent Antibody Dependent Cellular Phagocytosis With GM-CSF-Differentiated Macrophages
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FRONTIERS IN IMMUNOLOGY, 2019, 10
[10] Different dynamics of NLRP3 inflammasome-mediated IL-1β production in GM-CSF- and M-CSF-differentiated human macrophages
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