Efferocytosis Modulates Arginase-1 and Tyrosine Kinase Mer Expression in GM-CSF-Differentiated Human Macrophages

被引:0
|
作者
L. V. Sakhno
E. Ya. Shevela
M. A. Tikhonova
A. A. Maksimova
T. V. Tyrinova
A. A. Ostanin
E. R. Chernykh
机构
[1] Research Institute of Fundamental and Clinical Immunology,
来源
Bulletin of Experimental Biology and Medicine | 2021年 / 170卷
关键词
human macrophages; efferocytosis; arginase-1; tyrosine kinase Mer;
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学科分类号
摘要
We studied the expression of arginase-1 (Arg1) and tyrosine kinase Mer (MerTK) in GMCSF-differentiated human macrophage populations М0, М1(IFNγ), М2а(IL-4), and М2(low serum) generated under conditions of growth/serum factor deficiency. The maximum relative content of Arg1+ and MerTK+ cells was found in М2 macrophage populations: М2а(IL-4) and М2(low serum). As the uptake of apoptotic cells is the key mechanism of M2 polarization during M2(low serum) generation, we performed a special series of experiments and showed that incubation with allogeneic apoptotic neutrophils significantly increased the percentages of CD206+ macrophages co-expressing Arg1 and MerTK.
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页码:778 / 781
页数:3
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