The Safety of an Adenosine A1-Receptor Antagonist, Rolofylline, in Patients with Acute Heart Failure and Renal ImpairmentFindings from PROTECT

被引:0
作者
John R. Teerlink
Vicente J. Iragui
Jay P. Mohr
Peter E. Carson
Paul J. Hauptman
David H. Lovett
Alan B. Miller
Ileana L. Piña
Scott Thomson
Paul D. Varosy
Michael R. Zile
John G. F. Cleland
Michael M. Givertz
Marco Metra
Piotr Ponikowski
Adriaan A. Voors
Beth A. Davison
Gad Cotter
Denise Wolko
Paul DeLucca
Christina M. Salerno
George A. Mansoor
Howard Dittrich
Christopher M. O’Connor
Barry M. Massie
机构
[1] San Francisco Veterans Affairs Medical Center and University of California,
[2] San Francisco,undefined
[3] University of California,undefined
[4] San Diego,undefined
[5] Columbia University College of Physicians and Surgeons,undefined
[6] Washington DC Veterans Affairs Medical Center and Georgetown University,undefined
[7] St Louis University School of Medicine,undefined
[8] University of Florida Health Science Center,undefined
[9] Jacksonville,undefined
[10] Cleveland Veterans Affairs Medical Center and Case Western Reserve University,undefined
[11] San Diego Veterans Affairs Medical Center University of California,undefined
[12] San Diego,undefined
[13] Veterans Affairs Eastern Colorado Health Care System and University of Colorado Denver,undefined
[14] RHJ Department of Veterans Affairs Medical Center and Medical University of South Carolina,undefined
[15] University of Hull,undefined
[16] Brigham and Women’s Hospital,undefined
[17] University of Brescia,undefined
[18] Medical University,undefined
[19] Clinical Military Hospital,undefined
[20] University Medical Center Groningen,undefined
[21] Momentum Research,undefined
[22] Inc.,undefined
[23] Merck Research Laboratories,undefined
[24] Merck Research Laboratories,undefined
[25] NovaCardia,undefined
[26] Inc.,undefined
[27] Duke University Medical Center,undefined
[28] San Francisco Veterans Affairs Medical Center,undefined
[29] Section of Cardiology,undefined
来源
Drug Safety | 2012年 / 35卷
关键词
Atrial Fibrillation; Acute Heart Failure; Transient Ischaemic Attack; Stroke Rate; Focal Seizure;
D O I
暂无
中图分类号
学科分类号
摘要
Background: Adenosine exerts actions in multiple organ systems, and adenosine receptors are a therapeutic target in many development programmes.
引用
收藏
页码:233 / 244
页数:11
相关论文
共 56 条
  • [1] Kiesman WF(2009)A1 adenosine receptor antagonists, agonists, and allosteric enhancers Handb Exp Pharmacol 193 25-58
  • [2] Elzein E(2005)Adenosine and epilepsy: from therapeutic rationale to new therapeutic strategies Neuroscientist 11 25-36
  • [3] Zablocki J(2008)The PROTECT pilot study: a randomized, placebo-controlled, dosefinding study of the adenosine A1 receptor antagonist rolofylline in patients with acute heart failure and renal impairment J Card Fail 14 631-40
  • [4] Boison D(2010)Design and rationale of the PROTECT study: a placebo-controlled randomized study of the selective A1 adenosine receptor antagonist rolofylline for patients hospitalized with acute decompensated heart failure and volume overload to assess treatment effect on congestion and renal function J Card Fail 16 25-35
  • [5] Cotter G(2010)Rolofylline, an adenosine A N Engl J Med 363 1419-28
  • [6] Dittrich HC(1993)-receptor antagonist, in acute heart failure Stroke 24 35-41
  • [7] Weatherley BD(2006)Classification of subtype of acute ischemic stroke: definitions for use in a multicenter clinical trial. TOAST: Trial of Org 10172 in Acute Stroke Treatment Eur J Heart Fail 8 105-10
  • [8] Weatherley BD(2003)Clinical trials update from the American Heart Association: REPAIRAMI, ASTAMI, JELIS, MEGA, REVIVE-II, SURVIVE, and PROACTIVE J Am Coll Cardiol 41 997-1003
  • [9] Cotter G(2005)Heart failure etiology and response to milrinone in decompensated heart failure: results from the OPTIME-CHF study Annu Rev Pharmacol Toxicol 45 385-412
  • [10] Dittrich HC(2005)Actions of adenosine at its receptors in the CNS: insights from knockouts and drugs Curr Drug Targets CNS Neurol Disord 4 325-9