Cloning and Characterization of KLHL5, a Novel Human Gene Encoding a Kelch-Related Protein with a BTB Domain

被引：0
作者：
Shu Wang
Zongxiang Zhou
Kang Ying
Rong Tang
Yan Huang
Chaoqun Wu
Yi Xie
Yumin Mao
机构：
[1] Fudan University,Institute of Genetics, School of Life Science
来源：
Biochemical Genetics | 2001年 / 39卷
关键词：
human ; gene; kelch; BTB domain; BTB/kelch protein; actin binding;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Most kelch family proteins contain two conserved domains, the BTB domain and the kelch repeat domain. Here we describe the cloning and characterization of a novel human KLHL5 gene. The 3488 bp cDNA encodes a kelch family protein homologous to the Drosophila kelch protein. It also contains the two conserved domains. Northern blot analysis reveals a single transcript. It is abundantly expressed in ovary, adrenal gland, and thyroid and less abundantly expressed in trachea, prostate, testis, lymph node, and spinal cord. KLHL5 was mapped to 4p13–4p15.1.
引用
收藏
页码：227 / 238
页数：11
相关论文
共 12 条
  • [1] Cloning and characterization of KLHL5, a novel human gene encoding a kelch-related protein with a BTB domain
    Wang, S
    Zhou, ZX
    Ying, K
    Tang, R
    Huang, Y
    Wu, CQ
    Xie, Y
    Mao, YM
    BIOCHEMICAL GENETICS, 2001, 39 (7-8) : 227 - 238
  • [2] Characterization of a novel splicing variant of KLHL5, a member of the kelch protein family
    Xu, J
    Gu, SH
    Wang, S
    Dai, JL
    Ji, CN
    Jin, YS
    Qian, J
    Wang, L
    Ye, X
    Xie, Y
    Mao, YM
    MOLECULAR BIOLOGY REPORTS, 2003, 30 (04) : 239 - 242
  • [3] A Novel Human BTB-kelch Protein KLHL31, Strongly Expressed in Muscle and Heart, Inhibits Transcriptional Activities of TRE and SRE
    Yu, Weishi
    Li, Yongqing
    Zhou, Xijin
    Deng, Yun
    Wang, Zequn
    Yuan, Wuzhou
    Li, Dali
    Zhu, Chuanbing
    Zhao, Xueying
    Mo, Xiaoyang
    Huang, Wen
    Luo, Na
    Yan, Yan
    Ocorr, Karen
    Bodmer, Rolf
    Wang, Yuequn
    Wu, Xiushan
    MOLECULES AND CELLS, 2008, 26 (05) : 443 - 453
  • [4] Cloning and characterization of a novel human gene encoding a zinc finger protein with 25 fingers
    Li, XA
    Kokame, K
    Okubo, K
    Shimokado, K
    Tsukamoto, Y
    Miyata, T
    Kato, H
    Yutani, C
    BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION, 1999, 1489 (2-3): : 405 - 412
  • [5] Cloning and characterization of a novel human cDNA encoding a J-domain protein (DNAJA5) from the fetal brain
    Chen, JX
    Yin, G
    Lu, YC
    Lou, MQ
    Cheng, HP
    Ni, XH
    Hu, GH
    Luo, C
    Ying, K
    Xie, Y
    Ma, YM
    INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, 2004, 13 (05) : 735 - 740
  • [6] Molecular cloning and characterization of a novel human BTB domain-containing gene, BTBD10, which is down-regulated in glioma
    Chen, JX
    Xu, J
    Ying, K
    Cao, GT
    Hu, GH
    Wang, L
    Luo, C
    Lou, MQ
    Mao, YJ
    Xie, Y
    Lu, YC
    GENE, 2004, 340 (01) : 61 - 69
  • [7] Molecular cloning of ADIR, a novel interferon responsive gene encoding a protein related to the torsins
    Dron, M
    Meritet, JF
    Dandoy-Dron, F
    Meyniel, JP
    Maury, C
    Tovey, MG
    GENOMICS, 2002, 79 (03) : 315 - 325
  • [8] Molecular cloning and characterization of a novel human J-domain protein gene (HDJ3) from the fetal brain
    Chen, JX
    Yan, H
    Hai, W
    Ni, XH
    Cheng, HP
    Fan, JP
    Gu, SH
    Xing, G
    Cao, GT
    Ying, K
    Mao, YM
    Lu, YC
    Xie, Y
    JOURNAL OF HUMAN GENETICS, 2003, 48 (05) : 217 - 221
  • [9] Molecular cloning and characterization of a novel splice variant of the LIM domain family gene, PINCH 2, in human testis
    Yun Liu
    Jin Liu
    Jie Chen
    Libo Cheng
    Qinhong Cao
    Li Zhu
    Yan Sun
    Qinghuai Liu
    Jianmin Li
    Molecular Biotechnology, 2007, 35 : 109 - 118
  • [10] Molecular cloning and characterization of a novel splice variant of the LIM domain family gene, PINCH 2, in human testis
    Liu, Yun
    Liu, Jin
    Chen, Jie
    Cheng, Libo
    Cao, Qinhong
    Zhu, Li
    Sun, Yan
    Liu, Qinghuai
    Li, Jianmin
    MOLECULAR BIOTECHNOLOGY, 2007, 35 (02) : 109 - 118
12