Genistein suppresses aerobic glycolysis and induces hepatocellular carcinoma cell death

[1] Adlercreutz H(1993)Plasma concentrations of phyto-oestrogens in Japanese men Lancet 342 1209-1210

[2] Markkanen H(2015)Combination of genistein and cisplatin with two designed monofunctional platinum agents in human ovarian tumour Models Anticancer Res 35 6027-6039

[3] Watanabe S(2016)Facilitative glucose transporters: implications for cancer detection, prognosis and treatment Metabolism 65 124-139

[4] Arzuman L(2008)BNIP3 subfamily BH3-only proteins: mitochondrial stress sensors in normal and pathological functions Oncogene 27 S114-S127

[5] Beale P(2014)Anti-miR-197 inhibits migration in HCC cells by targeting KAI 1/CD82 Biochem Biophys Res Commun 446 541-548

[6] Proschogo N(2015)Genistein inhibits hepatocellular carcinoma cell migration by reversing the epithelial-mesenchymal transition: partial mediation by the transcription factor NFAT1 Mol Carcinog 54 301-311

[7] Yu JQ(2015)By reducing hexokinase 2, resveratrol induces apoptosis in HCC cells addicted to aerobic glycolysis and inhibits tumor growth in mice Oncotarget 6 13703-13717

[8] Huq F(2004)Hypoxia-mediated down-regulation of Bid and Bax in tumors occurs via hypoxia-inducible factor 1-dependent and -independent mechanisms and contributes to drug resistance Mol Cell Biol 24 2875-2889

[9] Barron CC(2016)Quantitative phosphoproteomics reveals genistein as a modulator of cell cycle and DNA damage response pathways in triple-negative breast cancer cells Int J Oncol 48 1016-1028

[10] Bilan PJ(2012)Genistein and bisphenol A exposure cause estrogen receptor 1 to bind thousands of sites in a cell type-specific manner Genome Res 22 2153-2162

[1] Adlercreutz H(1993)Plasma concentrations of phyto-oestrogens in Japanese men Lancet 342 1209-1210

[2] Markkanen H(2015)Combination of genistein and cisplatin with two designed monofunctional platinum agents in human ovarian tumour Models Anticancer Res 35 6027-6039

[3] Watanabe S(2016)Facilitative glucose transporters: implications for cancer detection, prognosis and treatment Metabolism 65 124-139

[4] Arzuman L(2008)BNIP3 subfamily BH3-only proteins: mitochondrial stress sensors in normal and pathological functions Oncogene 27 S114-S127

[5] Beale P(2014)Anti-miR-197 inhibits migration in HCC cells by targeting KAI 1/CD82 Biochem Biophys Res Commun 446 541-548

[6] Proschogo N(2015)Genistein inhibits hepatocellular carcinoma cell migration by reversing the epithelial-mesenchymal transition: partial mediation by the transcription factor NFAT1 Mol Carcinog 54 301-311

[7] Yu JQ(2015)By reducing hexokinase 2, resveratrol induces apoptosis in HCC cells addicted to aerobic glycolysis and inhibits tumor growth in mice Oncotarget 6 13703-13717

[8] Huq F(2004)Hypoxia-mediated down-regulation of Bid and Bax in tumors occurs via hypoxia-inducible factor 1-dependent and -independent mechanisms and contributes to drug resistance Mol Cell Biol 24 2875-2889

[9] Barron CC(2016)Quantitative phosphoproteomics reveals genistein as a modulator of cell cycle and DNA damage response pathways in triple-negative breast cancer cells Int J Oncol 48 1016-1028

[10] Bilan PJ(2012)Genistein and bisphenol A exposure cause estrogen receptor 1 to bind thousands of sites in a cell type-specific manner Genome Res 22 2153-2162