Role of Wnt1 and Fzd1 in the spinal cord pathogenesis of amyotrophic lateral sclerosis-transgenic mice

被引：0
作者：
Shanshan Wang
Yingjun Guan
Yanchun Chen
Xiaojin Li
Caixia Zhang
Li Yu
Fenghua Zhou
Xin Wang
机构：
[1] Weifang Medical University,Department of Histology and Embryology
[2] Brigham and Women’s Hospital,Department of Neurosurgery
[3] Harvard Medical School,undefined
来源：
Biotechnology Letters | 2013年 / 35卷
关键词：
Amyotrophic lateral sclerosis; Fzd1; SOD1; Wnt1; Wnt signaling pathway;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by chronic progressive degeneration of motor neurons resulting in muscular atrophy, paralysis, and ultimately death. We have investigated the expression of Wnt1 and Fzd1 in the spinal cords of SOD1G93A ALS transgenic mice, SOD1G93A-transfected N2a cells, and primary cultured astrocytes from SOD1G93A transgenic mice. In addition, we provided further insight into the role of Wnt1 and Fzd1 in the pathogenesis of ALS transgenic mice and discuss the mechanisms underlying the Wnt signal pathway which may be useful in the treatment of ALS. The results indicate the involvement of Wnt1 and Fzd1 in the pathogenesis and development of ALS.
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页码：1199 / 1207
页数：8
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