Curative potential of nonoperative treatment strategies for adenocarcinoma of the esophagogastric junction

被引:0
作者
Stahl, M. [1 ]
Stuschke, M. [2 ]
机构
[1] Evang Kliniken Essen Mitte, Klin Internist Onkol & Hamatol, Henricistr 92, D-45136 Essen, Germany
[2] Klinikum Univ Duisburg Essen, Klin & Poliklin Strahlentherapie, Essen, Germany
来源
ONKOLOGE | 2019年 / 25卷 / 12期
关键词
Surgery; Definitive chemoradiotherapy; Curative treatment; Retrospective cohort studies; Complete remission; ESOPHAGEAL CANCER; NEOADJUVANT CHEMORADIOTHERAPY; DEFINITIVE CHEMORADIOTHERAPY; RECURRENCE PATTERNS; SALVAGE SURGERY; CHEMORADIATION; THERAPY; CETUXIMAB; SURVIVAL; PLUS;
D O I
10.1007/s00761-019-00665-w
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Background Due to comorbidities and high age patients with localized adenocarcinoma of the esophagogastric junction (AEGJ) often have contraindications for surgery. Objective This raises the question of whether there are curative treatment options without surgery. Material and methods Following a nonsystematic search of the literature the published data on definitive chemoradiotherapy are reported. Results Retrospective cohort studies from centers in western countries show that patients with resectable AEGJ can have long-term survival and can possibly be cured by definitive chemoradiotherapy. Conclusion The treatment option of definitive chemoradiotherapy needs to be discussed in the interdisciplinary tumor board, not only for patients with squamous cell cancer of the esophagus but also for those with AEGJ. This is particularly true if complete remission has been clinically achieved.
引用
收藏
页码:1095 / 1102
页数:8
相关论文
共 50 条
  • [21] Multimodal Treatment and Supportive Care of Advanced Adenocarcinoma of the Esophagogastric Junction
    Block, Andreas
    Arnold, Dirk
    VISZERALMEDIZIN, 2012, 28 (02): : 121 - 127
  • [22] Adenocarcinoma of the esophagogastric junction: Neoadjuvant radiochemotherapy and radical surgery
    Leibl, Bernhard J.
    Vitz, Stephanie
    Schaefer, Wolfgang
    Alfrink, Martin
    Gschwendtner, Andreas
    Grabenbauer, Gerhard G.
    STRAHLENTHERAPIE UND ONKOLOGIE, 2011, 187 (04) : 231 - 237
  • [23] Treatment of esophago-gastric junction adenocarcinoma
    de Manzoni, Giovanni
    Zanoni, Andrea
    Giacopuzzi, Simone
    ANNALI ITALIANI DI CHIRURGIA, 2012, 83 (03) : 208 - 214
  • [24] Lack of EGFR mutations benefiting gefitinib treatment in adenocarcinoma of esophagogastric junction
    Wang, Wen-Ping
    Wang, Kang-Ning
    Gao, Qiang
    Chen, Long-Qi
    WORLD JOURNAL OF SURGICAL ONCOLOGY, 2012, 10
  • [25] Pretherapeutic misclassification of esophageal cancer and adenocarcinoma of the esophagogastric junction Possibilities and clinical consequences
    Gockel, I.
    Lordick, F.
    Lyros, O.
    Kreuser, N.
    Hoelscher, A. H.
    Wittekind, C.
    CHIRURG, 2020, 91 (01): : 41 - 50
  • [26] Prognostic Importance of the Preoperative Naples Prognostic Score for Patients With Adenocarcinoma of the Esophagogastric Junction
    Xiong, Jianping
    Wang, Yaqin
    Kang, Wenzhe
    Ma, Fuhai
    Liu, Hao
    Ma, Shuai
    Li, Yang
    Jin, Peng
    Hu, Haitao
    Tian, Yantao
    FRONTIERS IN ONCOLOGY, 2020, 10
  • [27] Treatment Strategies for the Optimal Management of Locally Advanced Pancreatic Adenocarcinoma With Curative Intent A Systematic Review
    Attard, Joseph A.
    Farrugia, Alexia
    Pathanki, Adithya
    Roberts, Keith J.
    Dasari, Bobby
    Isaac, John
    Ma, Yuk Ting
    Chatzizacharias, Nikolaos A.
    PANCREAS, 2020, 49 (10) : 1264 - 1275
  • [28] Treatment Patterns for Gastroesophageal Junction Adenocarcinoma in the United States †
    Kim, Bradford J.
    Chiang, Yi-Ju
    Das, Prajnan
    Minsky, Bruce D.
    Blum, Mariela A.
    Ajani, Jaffer A.
    Estrella, Jeannelyn S.
    Hofstetter, Wayne L.
    Tzeng, Ching-Wei D.
    Badgwell, Brian D.
    Mansfield, Paul F.
    Ikoma, Naruhiko
    JOURNAL OF CLINICAL MEDICINE, 2020, 9 (11) : 1 - 16
  • [29] Lymph node metastasis and lymphadenectomy of resectable adenocarcinoma of the esophagogastric junction
    Chen, Xin-Zu
    Zhang, Wei-Han
    Hu, Jian-Kun
    CHINESE JOURNAL OF CANCER RESEARCH, 2014, 26 (03) : 237 - 242
  • [30] The optimal lymph node dissection in patients with adenocarcinoma of the esophagogastric junction
    Okholm, Cecilie
    Fjederholt, Kaare Terp
    Mortensen, Frank Viborg
    Svendsen, Lars Bo
    Achiam, Michael Patrick
    SURGICAL ONCOLOGY-OXFORD, 2018, 27 (01): : 36 - 43