Revisiting the Hallmarks of Aging to Identify Markers of Biological Age

被引：0

作者：

Florent Guerville

P. De Souto Barreto

I. Ader

S. Andrieu

L. Casteilla

C. Dray

N. Fazilleau

S. Guyonnet

D. Langin

R. Liblau

A. Parini

P. Valet

N. Vergnolle

Y. Rolland

B. Vellas

机构：

[1] Toulouse University Hospital (CHU Toulouse),Gerontopole of Toulouse, Institute of Ageing

[2] University of Toulouse III,Inserm UMR1027

[3] Université Paul Sabatier,STROMALab, University of Toulouse, CNRS ERL5311, EFS, ENVT, Inserm U1031

[4] CHU Toulouse,Department of Epidemiology and Public Health

[5] University of Toulouse III,Institut des Maladies Métaboliques et Cardiovasculaires, Inserm UMR1048

[6] University of Toulouse III,Centre de Physiopathologie de Toulouse Purpan, Inserm UMR1043, CNRS UMR5282

[7] Toulouse University Hospital (CHU Toulouse),Department of Medical Biochemistry

[8] University of Toulouse III,Institut de Recherche en Santé Digestive, Inserm UMR1220, INRA UMR1416

[9] Gérontopôle de Toulouse,Institut du Vieillissement

来源：

The Journal of Prevention of Alzheimer's Disease | 2020年 / 7卷

关键词：

Biomarkers; biological age; healthy aging; frailty; geroscience;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

The Geroscience aims at a better understanding of the biological processes of aging, to prevent and/or delay the onset of chronic diseases and disability as well as to reduce the severity of these adverse clinical outcomes. Geroscience thus open up new perspectives of care to live a healthy aging, that is to say without dependency. To date, life expectancy in healthy aging is not increasing as fast as lifespan. The identification of biomarkers of aging is critical to predict adverse outcomes during aging, to implement interventions to reduce them, and to monitor the response to these interventions. In this narrative review, we gathered information about biomarkers of aging under the perspective of Geroscience. Based on the current literature, for each hallmark of biological aging, we proposed a putative biomarker of healthy aging, chosen for their association with mortality, age-related chronic diseases, frailty and/or functional loss. We also discussed how they could be validated as useful predictive biomarkers.

引用

页码：56 / 64

页数：8

共 295 条

[1] Seals DR(2016)Physiological geroscience: targeting function to increase healthspan and achieve optimal longevity: Translational physiology of ageing J Physiol 594 2001-24
[2] Justice JN(2018)Facing up to the global challenges of ageing Nature 561 45-56
[3] LaRocca TJ(2015)Accelerating aging research: how can we measure the rate of biologic aging? Exp Gerontol 64 78-80
[4] Partridge L(2017)Future life expectancy in 35 industrialised countries: projections with a Bayesian model ensemble The Lancet 389 1323-35
[5] Deelen J(2012)Ageing as a risk factor for disease Curr Biol 22 R741-R752
[6] Slagboom PE(1980)Aging, natural death, and the compression of morbidity N Engl J Med 303 130-5
[7] Margolick JB(2014)Translational geroscience: emphasizing function to achieve optimal longevity Aging 6 718-74
[8] Ferrucci L(2002)A program to prevent functional decline in physically frail, elderly persons who live at home N Engl J Med 347 1068-35
[9] Kontis V(2008)Complex interventions to improve physical function and maintain independent living in elderly people: a systematic review and meta-analysis Lancet Lond Engl 371 725-20
[10] Bennett JE(2019)The genetics of aging: a vertebrate perspective Cell 177 200-6

← 1 2 3 4 5 6 7 8 9 10 →