Understanding inflammatory pain: ion channels contributing to acute and chronic nociception

被引：0
作者：
John E. Linley
Kirstin Rose
Lezanne Ooi
Nikita Gamper
机构：
[1] University of Leeds,Institute of Membrane and Systems Biology, Faculty of Biological Sciences
来源：
Pflügers Archiv - European Journal of Physiology | 2010年 / 459卷
关键词：
Ion channels; Inflammation; Pain; Nociception;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Inflammatory pain results from the increased excitability of peripheral nociceptive sensory fibres produced by the action of inflammatory mediators. This excitatory effect, in turn, is a result of the altered activity of ion channels within affected sensory fibres. This review will consider the molecular consequences of inflammation within the peripheral nerves with particular focus on the effects of different inflammatory mediators on the ion channels in sensory neurons. We will discuss the main signalling pathways triggered in neurons by inflammatory mediators; the ionic mechanisms underlying inflammatory hyperalgesia and spontaneous inflammatory pain and finally will briefly consider ion channels underlying pain in chronic inflammation.
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页码：657 / 669
页数：12
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  • [1] Abrahamsen B(2008)The cell and molecular basis of mechanical, cold, and inflammatory pain Science 321 702-705
  • [2] Zhao J(1996)A tetrodotoxin-resistant voltage-gated sodium channel expressed by sensory neurons Nature 379 257-262
  • [3] Asante CO(2008)Interaction of transient receptor potential vanilloid 4, integrin, and SRC tyrosine kinase in mechanical hyperalgesia J Neurosci 28 1046-1057
  • [4] Cendan CM(2006)Protease-activated receptor 2 sensitises TRPV1 by protein kinase Cepsilon- and A-dependent mechanisms in rats and mice J Physiol 575 555-571
  • [5] Marsh S(2004)Protease-activated receptor 2 sensitises the capsaicin receptor transient receptor potential vanilloid receptor 1 to induce hyperalgesia J Neurosci 24 4300-4312
  • [6] Martinez-Barbera JP(2004)NGF and GDNF differentially regulate TRPV1 expression that contributes to development of inflammatory thermal hyperalgesia Eur J Neurosci 20 2303-2310
  • [7] Nassar MA(1992)Coupling of two endothelin receptor subtypes to differing signal transduction in transfected Chinese hamster ovary cells J Biol Chem 267 12468-12474
  • [8] Dickenson AH(2004)Noxious cold ion channel TRPA1 is activated by pungent compounds and bradykinin Neuron 41 849-857
  • [9] Wood JN(2009)The increased trafficking of the calcium channel subunit alpha2delta-1 to presynaptic terminals in neuropathic pain is inhibited by the alpha2delta ligand pregabalin J Neurosci 29 4076-4088
  • [10] Akopian AN(1995)Stimulation of cyclic GMP production via a nitrosyl factor in sensory neuronal cultures by algesic or inflammatory agents J Neurochem 65 363-372
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