Endometrial Abnormality in Women With Polycystic Ovary Syndrome

被引:1
作者
Kewei Shang
Xiao Jia
Jie Qiao
Jihong Kang
Youfei Guan
机构
[1] Peking University Health Science Center,Department of Physiology and Pathophysiology
[2] Peking University Third Hospital,Department of Obstetrics and Gynecology
来源
Reproductive Sciences | 2012年 / 19卷
关键词
polycystic ovary syndrome; infertility; endometrial abnormality;
D O I
暂无
中图分类号
学科分类号
摘要
Polycystic ovary syndrome (PCOS) is the most common endocrinopathy associated with infertility and metabolic disorder in women of reproductive age. Although the clinical and biochemical features are heterogeneous with individuals, the most widely accepted clinical characteristics of PCOS are oligo- or anovulation combined with hyperandrogenism. With the higher rate of implantation failure after induction of ovulation or higher risk of spontaneous miscarriage after pregnancy, the reduced fertility is apparently attributed not only to anovulation but also to endometrial dysfunction in patients with PCOS. Here we review the features of the endometrial abnormalities in women with PCOS. The ability to improve the endometrial functions is of potential therapeutic targets to increase reproductive outcome of women with PCOS.
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页码:674 / 683
页数:9
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共 356 条
[91]  
Kessler M(2004)Obesity reduces the expression of GLUT4 in the endometrium of normoinsulinemic women affected by the polycystic ovary syndrome Ann N Y Acad Sci 1034 364-39
[92]  
David R(2007)Peroxisome proliferator-activated receptor (PPAR) in metabolic syndrome and type 2 diabetes mellitus Curr Diabetes Rev 3 33-131
[93]  
Cheung AP(2010)Role of the transcriptional factors FOXO1 and PPARG on gene expression of SLC2A4 in endometrial tissue from women with polycystic ovary syndrome Reproduction 140 123-27219
[94]  
Peri N(2008)GLUT4 vesicle recruitment and fusion are differentially regulated by Rac, AS160, and Rab8A in muscle cells J Biol Chem 283 27208-293
[95]  
Levine D(2006)Insulin receptor signals regulating GLUT4 translocation and actin dynamics Endocr J 53 267-E45
[96]  
Tingthanatikul Y(2008)Transcriptional regulation of the insulinresponsive glucose transporter GLUT4 gene: from physiology to pathology Am J Physiol Endocrinol Metab 295 E38-403
[97]  
Choktanasiri W(2007)Ceramide- and oxidantinduced insulin resistance involve loss of insulin-dependent Rac-activation and actin remodeling in muscle cells Diabetes 56 394-2877
[98]  
Rochanawutanon M(2010)Levels of Rabs and WAVE family proteins associated with translocation of GLUT4 to the cell surface in endometria from hyperinsulinemic PCOS women Hum Reprod 25 2870-136
[99]  
Weerakeit S(2010)Changes in the expression of insulin signaling pathway molecules in endometria from polycystic ovary syndrome women with or without hyperinsulinemia Mol Med 16 129-771
[100]  
McCormick BA(2010)Extracellular signal-regulated protein kinase activation in endometrium with polycystic ovary syndrome and its significance [in Chinese] Zhonghua Fu Chan Ke Za Zhi 45 767-227