Genetics of macrovascular complications in diabetes

被引：12

作者：

Fumeron F. ^{[1
]}

Reis A.F. ^{[1
]}

Velho G. ^{[1
]}

机构：

[1] Inserm Unité 695, Faculté de Médecine Xavier Bichat, Paris 75018

来源：

Current Diabetes Reports | 2006年 / 6卷 / 2期

关键词：

Adiponectin Level; Macrovascular Complication; Arterioscler Thromb Vasc Biol; Serum Adiponectin Level; Plasma Adiponectin Level;

D O I：

10.1007/s11892-006-0028-5

中图分类号：

学科分类号：

摘要：

Diabetic patients have a threefold higher risk of developing atherosclerosis and its clinical complications compared with nondiabetic individuals. Part of the cardiovascular risk associated with diabetes is probably due to genetic determinants influencing both glucose homeostasis and the development of atherosclerosis. However, type 2 diabetes frequently coexists with other cardiovascular risk factors such as arterial hypertension, central obesity, and dyslipidemia. Genetic variability affects many areas, such as lipid and energy metabolisms, hypertension and hemodynamic mechanisms, blood clotting homeostasis, inflammation, and matrix turnover in the vascular wall, and will have an impact on the development of macrovascular complications in diabetic patients. These individual susceptibility factors each contribute only a small increased risk interacting with environmental determinants. Copyright © 2006 by Current Science Inc.

引用

页码：162 / 168

页数：6

共 49 条

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