Rapid induction of alternative lengthening of telomeres by depletion of the histone chaperone ASF1

被引：0
作者：
Roderick J O'Sullivan
Nausica Arnoult
Daniel H Lackner
Liana Oganesian
Candy Haggblom
Armelle Corpet
Genevieve Almouzni
Jan Karlseder
机构：
[1] Molecular and Cellular Biology Laboratory,
[2] The Salk Institute for Biological Studies,undefined
[3] Institut Curie,undefined
[4] Centre de Recherche,undefined
[5] Centre National de la Recherche Scientifique,undefined
[6] Present address: University Hospital of Zurich,undefined
[7] Zurich,undefined
[8] Switzerland.,undefined
来源：
Nature Structural & Molecular Biology | 2014年 / 21卷
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摘要：
Some cancer cells lacking telomerase activity extend their telomeres via an alternative, recombination-based mechanism, termed ALT. A new study shows that depletion of histone chaperone ASF1 can induce ALT in both primary and cancer cells, suggesting that the ALT pathway may be triggered by changes in chromatin state.
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页码：167 / 174
页数：7
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