Novel docetaxel-loaded nanoparticles based on poly(lactide-co-caprolactone) and poly(lactide-co-glycolide-co-caprolactone) for prostate cancer treatment: formulation, characterization, and cytotoxicity studies

被引：0
作者：
Vanna Sanna
Anna Maria Roggio
Anna Maria Posadino
Annalisa Cossu
Salvatore Marceddu
Alberto Mariani
Valeria Alzari
Sergio Uzzau
Gianfranco Pintus
Mario Sechi
机构：
[1] Località Tramariglio,Porto Conte Ricerche
[2] Alghero,Department of Biomedical Sciences, Centre of Excellence for Biotechnology Development and Biodiversity Research
[3] University of Sassari,Department of Chemistry and local INSTM unit
[4] Istituto di Scienze delle Produzioni Alimentari (ISPA),Dipartimento di Scienze del Farmaco
[5] CNR,undefined
[6] University of Sassari,undefined
[7] University of Sassari,undefined
来源：
Nanoscale Research Letters | / 6卷
关键词：
Drug Release; Pluronic; Encapsulation Efficiency; Caprolactone; Human Prostate Cancer Cell Line;
D O I：
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中图分类号：
学科分类号：
摘要：
Docetaxel (Dtx) chemotherapy is the optional treatment in patients with hormone-refractory metastatic prostate cancer, and Dtx-loaded polymeric nanoparticles (NPs) have the potential to induce durable clinical responses. However, alternative formulations are needed to overcome the serious side effects, also due to the adjuvant used, and to improve the clinical efficacy of the drug.
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