Aptamer and its applications in neurodegenerative diseases

被引：0
作者：
Jing Qu
Shuqing Yu
Yuan Zheng
Yan Zheng
Hui Yang
Jianliang Zhang
机构：
[1] Capital Medical University,Department of Neurobiology, Beijing Institute of Brain Disorders, Key Laboratory for Neurodegenerative Disease of the Ministry of Education, Beijing Center of Neural Regeneration and Repair, Beijing Key Laboratory of Brain Major
[2] Capital Medical University,State Key Lab Incubation Base, Beijing Neuroscience Disciplines
来源：
Cellular and Molecular Life Sciences | 2017年 / 74卷
关键词：
Aptamer; Neurodegenerative diseases; Alzheimer’s disease; Parkinson’s disease; Transmissible spongiform encephalopathy; Huntington’s disease; Multiple sclerosis;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Aptamers are small single-stranded DNA or RNA oligonucleotide fragments or small peptides, which can bind to targets by high affinity and specificity. Because aptamers are specific, non-immunogenic and non-toxic, they are ideal materials for clinical applications. Neurodegenerative disorders are ravaging the lives of patients. Even though the mechanism of these diseases is still elusive, they are mainly characterized by the accumulation of misfolded proteins in the central nervous system. So it is essential to develop potential measures to slow down or prevent the onset of these diseases. With the advancements of the technologies, aptamers have opened up new areas in this research field. Aptamers could bind with these related target proteins to interrupt their accumulation, subsequently blocking or preventing the process of neurodegenerative diseases. This review presents recent advances in the aptamer generation and its merits and limitations, with emphasis on its applications in neurodegenerative diseases including Alzheimer’s disease, Parkinson’s disease, transmissible spongiform encephalopathy, Huntington’s disease and multiple sclerosis.
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页码：683 / 695
页数：12
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