Determination of ED50 and time to effectiveness for intrathecal hydromorphone in laboring patients using Dixon’s up-and-down sequential allocation method

[1] Bottros MM(2014)Current perspectives on intrathecal drug delivery J Pain Res. 7 615-626

[2] Christo PJ(2012)Polyanalgesic Consensus Conference 2012: recommendations for the management of pain by intrathecal (intraspinal) drug delivery: report of an interdisciplinary expert panel Neuromodulation. 15 436-464

[3] Deer TR(2017)What’s new in clinical obstetric anesthesia in 2015? Int J Obstet Anesth. 32 54-63

[4] Prager J(2012)Comparison of efficacy of sufentanil and fentanyl with low-concentration bupivacaine for combined spinal epidural labour analgesia Indian J Anaesth. 56 365-369

[5] Levy R(2007)Intrathecal morphine reduces breakthrough pain during labour epidural analgesia Br J Anaesth. 98 241-245

[6] Rathmell J(1995)Lipid solubility and epidural opioid efficacy Anesthesiology. 83 427-428

[7] Buchser E(2013)The median local analgesic dose of intrathecal bupivacaine with hydromorphone for labour: a double-blind randomized controlled trial Can J Anaesth. 60 1061-1069

[8] Burton A(1965)The Up-and-Down Method for Small Samples J Am Stat Assoc. 60 967-978

[9] Hess PE(2002)Dose finding using the biased coin up-and-down design and isotonic regression Biometrics. 58 171-177

[10] Akkamahadevi P(1997)A random walk rule for phase I clinical trials Biometrics. 53 745-760

[1] Bottros MM(2014)Current perspectives on intrathecal drug delivery J Pain Res. 7 615-626

[2] Christo PJ(2012)Polyanalgesic Consensus Conference 2012: recommendations for the management of pain by intrathecal (intraspinal) drug delivery: report of an interdisciplinary expert panel Neuromodulation. 15 436-464

[3] Deer TR(2017)What’s new in clinical obstetric anesthesia in 2015? Int J Obstet Anesth. 32 54-63

[4] Prager J(2012)Comparison of efficacy of sufentanil and fentanyl with low-concentration bupivacaine for combined spinal epidural labour analgesia Indian J Anaesth. 56 365-369

[5] Levy R(2007)Intrathecal morphine reduces breakthrough pain during labour epidural analgesia Br J Anaesth. 98 241-245

[6] Rathmell J(1995)Lipid solubility and epidural opioid efficacy Anesthesiology. 83 427-428

[7] Buchser E(2013)The median local analgesic dose of intrathecal bupivacaine with hydromorphone for labour: a double-blind randomized controlled trial Can J Anaesth. 60 1061-1069

[8] Burton A(1965)The Up-and-Down Method for Small Samples J Am Stat Assoc. 60 967-978

[9] Hess PE(2002)Dose finding using the biased coin up-and-down design and isotonic regression Biometrics. 58 171-177

[10] Akkamahadevi P(1997)A random walk rule for phase I clinical trials Biometrics. 53 745-760