Long non-coding RNA H19 in atherosclerosis: what role?

被引：0
作者：
Xian Shi
Ya-Ting Wei
Heng Li
Ting Jiang
Xi-Long Zheng
Kai Yin
Guo-Jun Zhao
机构：
[1] Guilin Medical University,School of Medicine
[2] University of South China,Institute of Cardiovascular Research, Key Laboratory for Arteriosclerology of Hunan Province
[3] Qingyuan City People’s Hospital,The Sixth Affiliated Hospital of Guangzhou Medical University
[4] The University of Calgary,Department of Biochemistry and Molecular Biology, The Libin Cardiovascular Institute of Alberta
[5] Health Sciences Center,Key Laboratory of Molecular Targets and Clinical Pharmacology, School of Pharmaceutical Sciences
[6] Guangzhou Medical University,Center for Diabetic Systems Medicine, Guangxi Key Laboratory of Excellence
[7] The Second Affiliated Hospital of Guilin Medical University,undefined
来源：
Molecular Medicine | 2020年 / 26卷
关键词：
LncRNA-H19; Angiogenesis; Lipid metabolism; Inflammatory response; Atherosclerosis;
D O I：
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学科分类号：
摘要：
Atherosclerosis (AS) is widely accepted to be a multistep pathophysiological process associated with several other processes such as angiogenesis and inflammatory response. Long non-coding RNAs (lncRNAs) are non-protein coding RNAs (more than 200 nucleotides in length) and can regulate gene expression at the transcriptional and post-transcriptional levels. Recent studies suggest that lncRNA-H19 plays important roles in the regulation of angiogenesis, adipocyte differentiation, lipid metabolism, inflammatory response, cellular proliferation and apoptosis. In this review, we primarily discuss the roles of lncRNA-H19 in atherosclerosis-related pathophysiological processes and the potential mechanisms by which lncRNA-H19 regulates the development of atherosclerosis, to help provide a better understanding of the biological functions of lncRNA-H19 in atherosclerosis.
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