Molecular construction of multitarget neuroprotectors 4.* Synthesis and biological activity of conjugates of carbazoles and tetrahydrocarbazoles

被引：0
|
作者：
V. B. Sokolov
A. Yu. Aksinenko
T. V. Goreva
T. A. Epishina
L. G. Dubova
E. S. Dubrovskaya
S. G. Klochkov
P. N. Shevtsov
E. F. Shevtsova
S. O. Bachurin
机构：
[1] Russian Academy of Sciences,Institute of Physiologically Active Substances
来源：
Russian Chemical Bulletin | 2016年 / 65卷
关键词：
carbazoles; tetrahydrocarbazoles; 3,6-substituted 9-oxiranylmethylcarbazoles; 2,8-substituted 2,3,4,5-tetrahydro-1; -pyrido[4,3-; ]indoles; 1-(9; -carbazol-9-yl)-3-(1,2,3,4-tetrahydro-5; -pyrido[4,3-; ]indol-5-yl)propan-2-ones; catalytic alkylation; mitochondria; neuroprotection; mitochondrial permeability transition; tubulin; glutamate toxicity;
D O I：
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中图分类号：
学科分类号：
摘要：
Unknown conjugates of carbazoles and tetrahydrocarbazoles were obtained by the alkylation of carbazoles and tetrahydrocarbazoles with 3,6-substituted 9-oxiranylmethylcarbazoles. The influence of synthesized 1-(9Н-carbazol-9-yl)-3-(1,2,3,4-tetrahydro-5Н-pyrido[4,3-b]-indol-5-yl)propan-2-ones on functional characteristics of brain mitochondria has been studied. The potential neuroprotective activity of a several representatives of conjugates has been demonstrated using glutamate toxicity model.
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页码：2306 / 2311
页数：5
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