The Effect of Porphyromonas gingivalis Lipopolysaccharide on the Pyroptosis of Gingival Fibroblasts

被引：0
|
作者：
Yu-Yang Li
Qing Cai
Bao-Sheng Li
Shu-Wei Qiao
Jia-Yang Jiang
Dan Wang
Xue-Chun Du
Wei-Yan Meng
机构：
[1] Jilin University,Department of Dental Implantology, Hospital of Stomatology
[2] Jilin Provincial Key Laboratory of Tooth Development and Bone Remodeling,undefined
来源：
Inflammation | 2021年 / 44卷
关键词：
lipopolysaccharide; fibroblast; programmed cell death; pyroptosis;
D O I：
暂无
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学科分类号：
摘要：
Periodontitis is a chronic inflammatory disease induced by Porphyromonas gingivalis (P. gingivalis) and other pathogens. P. gingivalis release various virulence factors including lipopolysaccharide (LPS). However, whether P. gingivalis–LPS inducing pyroptosis in human gingival fibroblasts (HGFs) remains unknown. In present study, P. gingivalis–LPS decreased the membrane integrity of HGFs, and pyroptosis-associated cytokines were upregulated at the mRNA level. In addition, pyroptosis proteins were highly expressed in gingival tissues of periodontitis. P. gingivalis–LPS induced gingivitis in the rat model, and the expression level of pyroptosis-associated proteins increased. Together, P. gingivalis–LPS can activate the pyroptosis reaction, which may be a pro-pyroptosis status in a relative low concentration.
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页码：846 / 858
页数：12
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