Triterpenoid fromTiarella polyphylla, regulation of type 1 procollagen and MMP-1 in ultraviolet irradiation of cultured old age human dermal fibroblasts

被引：0
作者：
Hyung -In Moon
Joongku Lee
Ok Pyo Zee
Jin Ho Chung
机构：
[1] Seoul National University,Department of Dermatology
[2] Seoul National University Hosipital,Laboratory of Cutaneous Aging Research, College of Medicine, and Clinical Research Institute
[3] Korea Research Institute of Bioscience and Biotechnology,College of Pharmacy
[4] SungKyunKwan University,undefined
来源：
Archives of Pharmacal Research | 2004年 / 27卷
关键词：
3; 23-Dihydroxy-20(29)-lupen-27-oic acid; MMP-1, Type 1- procollagen; Ultraviolet irradiation; Old age human dermal fibroblasts;
D O I：
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中图分类号：
学科分类号：
摘要：
Although many studies have been performed to elucidate the molecular consequences of ultraviolet irradiation, little is known about the effect of natural products. Ultraviolet irradiation is widely considered to be an environmental stress. Here we investigated the effect of 3,23-dihy-droxy-20(29)-lupen-27-oic acid on the regulation of MMP-1 and type 1 procollagen in Ultraviolet irradiation of cultured old age human dermal fibroblasts. 3, 23-dihydroxy-20(29)-lupen-27-oic acid was isolated fromTiarella polyphylla D. Don (Saxifragaceae). Among them, 3, 23-dihydroxy-20(29)-lupen-27-oic acid induced the regulation of Type 1- procollagen and reduced the regulation of MMP-1 at the protein levels in a dose-dependent manner by ultraviolet irradiation. Taken together, our results suggest that 3, 23-dihydroxy-20(29)-lupen-27-oic acid plays an important role in the induction of Type 1-procollagen and reduction of MMP-1 by ultraviolet irradiation in old age human dermal fibroblasts.
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页码：1060 / 1064
页数：4
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