Development of a 3D functional assay and identification of biomarkers, predictive for response of high-grade serous ovarian cancer (HGSOC) patients to poly-ADP ribose polymerase inhibitors (PARPis): targeted therapy

被引：0
作者：
Razan Sheta
Magdalena Bachvarova
Marie Plante
Marie-Claude Renaud
Alexandra Sebastianelli
Jean Gregoire
Jamilet Miranda Navarro
Ricardo Bringas Perez
Jean-Yves Masson
Dimcho Bachvarov
机构：
[1] Université Laval,Department of Molecular Medicine
[2] Centre de recherche du CHU de Québec,Department of Obstetrics and Gynecology
[3] Oncology division,Department of Molecular Biology, Medical Biochemistry, and Pathology
[4] L’Hôtel-Dieu de Québec,undefined
[5] Université Laval,undefined
[6] Bioinformatics Department,undefined
[7] Center for Genetic Engineering and Biotechnology,undefined
[8] Laval University Cancer Research Center,undefined
来源：
Journal of Translational Medicine | / 18卷
关键词：
High-grade serous ovarian cancer; PARP inhibitors homologous recombination repair pathway; Functional assay; Ascites; Primary cell cultures; 3D cellular model; Spheroids; Epithelial-to-mesenchymal transition; Biomarkers;
D O I：
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