Study of thrombophilia in recurrent pregnancy loss

被引：9
作者：
Hansda J. [1 ,2 ,3 ]
Roychowdhury J. [2 ]
机构：
[1] NRS Medical College, Kolkata
[2] Department of OBGY, ESI-Postgraduate Institute and Medical Research, Joka, Kolkata
[3] C/O-Sri R C Hansda, Durgapur, Burdwan, 713205 WB Kolkata, 2/2 Krittibas Road (South), B-Zone
来源：
The Journal of Obstetrics and Gynecology of India | 2012年 / 62卷 / 5期
关键词：
Preterm Birth; Bacterial Vaginosis; Pregnancy Loss; Pregnancy Complication; Thrombophilia;
D O I：
10.1007/s13224-012-0197-x
中图分类号：
学科分类号：
摘要：
Objectives: Recently, it has been found that women who have thrombophilia have increased risk of fetal loss. This study was designed to corroborate the association of elevated factor VIII level, protein C and protein S deficiencies, and the presence of LAC in women with recurrent pregnancy loss. Materials and Methods: 53 patients with history of two or more pregnancy losses and 47 healthy age-matched subjects with no history of pregnancy loss and who have delivered at least one term infant without any complication were enrolled into the study. Results: Thrombophilic defect was present in 64.15 % of patients of study group. Protein S deficiency (50.94 %) was the most common thrombophilic defect observed. Spontaneous abortion (SA), preterm birth (PTB), and intrauterine growth retardation (IUGR) were the most important pregnancy complications observed. The strongest associations of pregnancy complications were observed with protein S deficiency (87.5 %) and with elevated factor VIII (66.66 %) level. Conclusion: This study observed strong association of thrombophilia with unexplained recurrent pregnancy loss. © 2012 Federation of Obstetric & Gynecological Societies of India.
引用
收藏
页码：536 / 540
页数：4
相关论文
共 20 条
  • [11] De Sancho M.T., Richardson L., Rand J.H., Prevalence of thrombophilia in women with spontaneous pregnancy loss, Blood, (2004)
  • [12] Robertson L., Wu O., Langhorne P., Twaddle S., Clark P., Lowe G.D.O., Walker I.D., Greaves M., Brenkel I., Regan L., Greer I.A., Thrombophilia in pregnancy: A systematic review, British Journal of Haematology, 132, 2, pp. 171-196, (2006)
  • [13] Sarig G., Younis J.S., Hoffman R., Lanir N., Blumenfeld Z., Brenner B., Thrombophilia is common in women with idiopathic pregnancy loss and is associated with late pregnancy wastage, Fertility and Sterility, 77, 2, pp. 342-347, (2002)
  • [14] D'Uva M., Di Micco P., Strina I., Ranieri A., Alviggi C., Mollo A., Fabozzi F., Cacciapuoti L., Di Frega M.T.S., Iannuzzo M., De Placido G., Etiology of hypercoagulable state in women with recurrent fetal loss without other causes of miscarriage from Southern Italy: New clinical target for antithrombotic therapy, Biol Targets Therapy, 2, 4, pp. 897-902, (2008)
  • [15] Ulander V.-M., Palosuo T., Kaaja R., Acquired and hereditary thrombophilia and recurrent miscarriage, J Thromb Haemost, 3, SUPPL. 1, (2005)
  • [16] Many A., Elad R., Yaron Y., Eldor A., Lessing J.B., Kupferminc M.J., Third-trimester unexplained intrauterine fetal death is associated with inherited thrombophilia, Obstetrics and Gynecology, 99, 5, pp. 684-687, (2002)
  • [17] Karimi M., Afrasiabi R., Zolghadri Z., Et al., Influence of inherited thrombophilia with recurrent pregnancy loss, J Thromb Haemost, 5, SUPPL. 2, (2007)
  • [18] Marietta M., Facchinetti F., Sgarbi L., Simoni L., Bertesi M., Torelli G., Volpe A., Elevated plasma levels of factor VIII in women with recurrent miscarriage, J Thromb Haemost, 1, 12, pp. 2536-2539, (2003)
  • [19] Hossain N., Shamsi T., Soomro N., Frequency of thrombophilia in patients with adverse pregnancy outcome, JPMA, 55, 245, (2005)
  • [20] Tulppala M., Palosuo T., Ramsay T., Miettinen A., Salonen R., Ylikorkala O., A prospective study of 63 couples with a history of recurrent spontaneous abortion: Contributing factors and outcome of subsequent pregnancies, Human Reproduction, 8, 5, pp. 764-770, (1993)
12