Study of thrombophilia in recurrent pregnancy loss

被引：9
作者：
Hansda J. [1 ,2 ,3 ]
Roychowdhury J. [2 ]
机构：
[1] NRS Medical College, Kolkata
[2] Department of OBGY, ESI-Postgraduate Institute and Medical Research, Joka, Kolkata
[3] C/O-Sri R C Hansda, Durgapur, Burdwan, 713205 WB Kolkata, 2/2 Krittibas Road (South), B-Zone
来源：
The Journal of Obstetrics and Gynecology of India | 2012年 / 62卷 / 5期
关键词：
Preterm Birth; Bacterial Vaginosis; Pregnancy Loss; Pregnancy Complication; Thrombophilia;
D O I：
10.1007/s13224-012-0197-x
中图分类号：
学科分类号：
摘要：
Objectives: Recently, it has been found that women who have thrombophilia have increased risk of fetal loss. This study was designed to corroborate the association of elevated factor VIII level, protein C and protein S deficiencies, and the presence of LAC in women with recurrent pregnancy loss. Materials and Methods: 53 patients with history of two or more pregnancy losses and 47 healthy age-matched subjects with no history of pregnancy loss and who have delivered at least one term infant without any complication were enrolled into the study. Results: Thrombophilic defect was present in 64.15 % of patients of study group. Protein S deficiency (50.94 %) was the most common thrombophilic defect observed. Spontaneous abortion (SA), preterm birth (PTB), and intrauterine growth retardation (IUGR) were the most important pregnancy complications observed. The strongest associations of pregnancy complications were observed with protein S deficiency (87.5 %) and with elevated factor VIII (66.66 %) level. Conclusion: This study observed strong association of thrombophilia with unexplained recurrent pregnancy loss. © 2012 Federation of Obstetric & Gynecological Societies of India.
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页码：536 / 540
页数：4
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