Protective Effect of Resveratrol against Kainate-induced Temporal Lobe Epilepsy in Rats

被引：0
作者：
Zheng Wu
Qi Xu
Lei Zhang
Dehu Kong
Rong Ma
Liecheng Wang
机构：
[1] Anhui Medical University,Department of Physiology, School of Basic Medical Science
[2] Fudan University,Institute of Brain Science
[3] Anhui College of Traditional Chinese Medicine,Department of Physiology
[4] University of North Texas Health Science Center,Department of Integrative Physiology
来源：
Neurochemical Research | 2009年 / 34卷
关键词：
Resveratrol; Epilepsy; Kainate; Kainate receptor; Neuronal cell loss; Temporal lobe epilepsy;
D O I：
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中图分类号：
学科分类号：
摘要：
Resveratrol (Res) is a phytoalexin produced naturally by several plants, which has multi functional effects such as neuroprotection, anti-inflammatory, and anti-cancer. The present study was to evaluate a possible anti-epileptic effect of Res against kainate-induced temporal lobe epilepsy (TLE) in rat. We performed behavior monitoring, intracranial electroencepholography (IEEG) recording, histological analysis, and Western blotting to evaluate the anti-epilepsy effect of Res in kainate-induced epileptic rats. Res decreased the frequency of spontaneous seizures and inhibited the epileptiform discharges. Moreover, Res could protect neurons against kainate-induced neuronal cell death in CA1 and CA3a regions and depressed mossy fiber sprouting, which are general histological characteristics both in TLE patients and animal models. Western blot revealed that the expression level of kainate receptors (KARs) in hippocampus was reduced in Res-administrated rats compared to that in epileptic ones. These results suggest that Res is a potent anti-epilepsy agent, which protects against epileptogenesis and progression of the kainate-induced TLE animal.
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