Oral field cancerization: Current evidence and future perspectives

被引：77
作者：
Punnya V. Angadi
J. K. Savitha
Sanjay S. Rao
Y. Sivaranjini
机构：
[1] KLE VK Institute of Dental Sciences and Hospital
[2] Raja Rajeshwari Dental College, Bangalore, Karnataka
[3] Mamata Dental College, Khammam, Andhra Pradesh
来源：
Oral and Maxillofacial Surgery | 2012年 / 16卷 / 2期
关键词：
Field cancerization; Oral cancer; Premalignant lesions; Tobacco;
D O I：
10.1007/s10006-012-0317-x
中图分类号：
学科分类号：
摘要：
Introduction: Oral field cancerization implies that oral cancer does not arise as an isolated cellular phenomenon but rather as an anaplastic tendency involving many cells at once and results in the multifocal development of cancer at various rates within the entire field in response to a carcinogen especially tobacco. This concept has been frequently used to explain the occurrence of multiple primary cancers and recurrences following complete excision of oral cancer. Discussion: This review deals in detail with the origin, principle, various theories used to explain this effect and molecular, genetic, as well as cytogenetic findings related to oral field cancerization. Further, the clinical implications and future research directives are also discussed. © 2012 Springer-Verlag.
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页码：171 / 180
页数：9
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