Oral field cancerization: Current evidence and future perspectives

被引：77
作者：
Punnya V. Angadi
J. K. Savitha
Sanjay S. Rao
Y. Sivaranjini
机构：
[1] KLE VK Institute of Dental Sciences and Hospital
[2] Raja Rajeshwari Dental College, Bangalore, Karnataka
[3] Mamata Dental College, Khammam, Andhra Pradesh
来源：
Oral and Maxillofacial Surgery | 2012年 / 16卷 / 2期
关键词：
Field cancerization; Oral cancer; Premalignant lesions; Tobacco;
D O I：
10.1007/s10006-012-0317-x
中图分类号：
学科分类号：
摘要：
Introduction: Oral field cancerization implies that oral cancer does not arise as an isolated cellular phenomenon but rather as an anaplastic tendency involving many cells at once and results in the multifocal development of cancer at various rates within the entire field in response to a carcinogen especially tobacco. This concept has been frequently used to explain the occurrence of multiple primary cancers and recurrences following complete excision of oral cancer. Discussion: This review deals in detail with the origin, principle, various theories used to explain this effect and molecular, genetic, as well as cytogenetic findings related to oral field cancerization. Further, the clinical implications and future research directives are also discussed. © 2012 Springer-Verlag.
引用
收藏
页码：171 / 180
页数：9
相关论文
共 81 条
[1]  
Slaughter D.P., Southwick H.W., Smejkal W., Field cancerization in oral stratified squamous epithelium: clinical implication of multicentric origin, Cancer, 6, pp. 963-968, (1953)
[2]  
Slaughter D.P., The multiplicity of origin of malignant tumors: collective review, Internat Abstr Surg, 79, pp. 89-98, (1944)
[3]  
Slaughter D.P., Multicentric origin of intraoral carcinoma, Surgery, 20, pp. 133-135, (1946)
[4]  
Boudewijn J.M., Braakhuis T., Tabor M.T., Kumar J.A., Leemans R., Barkenhoff R.H., Et al., A genetic explanation of slaughter's concept of field cancerization: evidence and clinical implications, Cancer Res, 63, pp. 1727-1730, (2003)
[5]  
Ogden G.R., Cowpe J.G., Green M.W., Evidence of field change in oral cancer, Br J Oral Maxillofac Surg, 28, pp. 390-392, (1990)
[6]  
Gabriel D.D., Jakupciak P.J., Machin M., Parr R., Clinical implications and utility of field cancerization, Cancer Cell Int, 7, (2007)
[7]  
Monique G., Oijen V., Slootweg P.J., Oral field cancerization: carcinogen-induced independent events or micrometastic deposits?, Cancer Epidemiol Biomarkers Prev, 9, pp. 249-256, (2000)
[8]  
van Houten V.M., Leemans C.R., Kummer J.A., Dijkstra J., Kuik D.J., van den Brekel M.W., Snow G.B., Brakenhoff R.H., Molecular diagnosis of surgical margins and local recurrence in head and cancer patients: a prospective study, Clin Cancer Res, 10, pp. 3614-3620, (2004)
[9]  
Califano J., van der Riet P., Westra W., Nawroz H., Clayman G., Piantadosi S., Et al., Genetic progression model for head and neck cancer: implications for field cancerization, Cancer Res, 56, pp. 2488-2492, (1996)
[10]  
Bedi G.C., Westra W.H., Gabrielson E., Koch W., Sidransky D., Multiple head and neck tumors: evidence for common clonal origin, Cancer Res, 56, pp. 2484-2487, (1996)
123456789