Coexistence of BCL1/CCND1 and CMYC aberrations in blastoid mantle cell lymphoma: a rare finding associated with very poor outcome

被引：0
|
作者：
L. Michaux
I. Wlodarska
I. Theate
M. Stul
J.-M. Scheiff
V. Deneys
A. Ferrant
A. Hagemeijer
机构：
[1] Cliniques universitaires UCL St Luc,Department of Hematology, Clinical Biology and Pathology
[2] University of Leuven,Center for Human Genetics
来源：
Annals of Hematology | 2004年 / 83卷
关键词：
Mantle cell lymphoma; Blastoid; CMYC;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
A patient with mantle cell lymphoma (MCL) of the pleomorphic blastoid subtype is reported. The disease was clinically aggressive and refractory to chemotherapy, and the patient survived only 2 months. Cytogenetically, a t(11;19;14)(q13;q13;q32) was found. Fluorescent in situ hybridization (FISH) and molecular analyses demonstrated involvement of the BCL1/CCND1 locus in a three-way translocation. In addition, subclonal abnormalities of the region 8q24 manifested either as a t(8;22)(q24;q11)/CMYC rearrangement or trisomy 8 were identified. The pathogenetic impact of this very uncommon association of BCL1/CCND1 and CMYC rearrangements in MCL is discussed and the literature is reviewed.
引用
收藏
页码：578 / 583
页数：5
相关论文
共 50 条
  • [41] An aggressive B-cell lymphoma with rearrangements of MYC and CCND1 genes: a rare subtype of double-hit lymphoma
    Durot, Eric
    Patey, Martine
    Luquet, Isabelle
    Gaillard, Baptiste
    Kolb, Brigitte
    Delmer, Alain
    LEUKEMIA & LYMPHOMA, 2013, 54 (03) : 649 - 652
  • [42] Cyclin D1+large B-cell lymphoma with altered CCND1 and BCL-6 rearrangements: a diagnostic challenge
    Gao, Da
    Liu, Zach
    BIOMARKER RESEARCH, 2019, 7
  • [43] Molecular cytogenetic study of a mantle cell lymphoma with a complex translocation involving the CCND1 (11q 13) region
    Maravelaki, S
    Burford, A
    Wotherspoon, A
    Joshi, R
    Matutes, E
    Catovsky, D
    Brito-Babapulle, V
    CANCER GENETICS AND CYTOGENETICS, 2004, 154 (01) : 67 - 71
  • [44] Insertion of the CCND1 gene into the IgH locus in a case of leukaemic small cell mantle lymphoma with normal chromosomes 11 and 14
    Aventín, A
    Nomdedéu, J
    Briones, J
    Espinosa, I
    Bordes, R
    Sierra, J
    JOURNAL OF CLINICAL PATHOLOGY, 2003, 56 (10) : 798 - 800
  • [45] Cryptic insertions of the immunoglobulin light chain enhancer region near CCND1 in t(11;14)-negative mantle cell lymphoma
    Fuster, Carla
    Martin-Garcia, David
    Balague, Olga
    Navarro, Alba
    Nadeu, Ferran
    Costa, Dolors
    Prieto, Miriam
    Salaverria, Itziar
    Espinet, Blanca
    Rivas-Delgado, Alfredo
    Terol, Maria Jose
    Gine, Eva
    Forcada, Pilar
    Ashton-Key, Margaret
    Puente, Xose S.
    Swerdlow, Steven H.
    Bea, Silvia
    Campo, Elias
    HAEMATOLOGICA, 2020, 105 (08) : E408 - E411
  • [46] A TECHNICAL COMPARISON BETWEEN IGH AND BCL1/IGH MOLECULAR MARKERS FOR MINIMAL RESIDUAL DISEASE ANALYSIS IN MANTLE CELL LYMPHOMA
    Ghione, P.
    Monitillo, L.
    Barbero, D.
    Verardo, G.
    Drandi, D.
    Grimaldi, D.
    Genuardi, E.
    Mantoan, B.
    Cavallo, F.
    Vasta, M.
    Zaja, F.
    Visco, C.
    Cortelazzo, S.
    Boccadoro, M.
    Ladetto, M.
    Ferrero, S.
    HAEMATOLOGICA, 2016, 101 : S43 - S44
  • [47] BCL-1 (PRAD-1 cyclin D-1) overexpression distinguishes the blastoid variant of mantle cell lymphoma from B-lineage lymphoblastic lymphoma
    Soslow, RA
    Zukerberg, LR
    Harris, NL
    Warnke, RA
    MODERN PATHOLOGY, 1997, 10 (08) : 810 - 817
  • [48] A cyclin D1-negative mantle cell lymphoma with an IGL-CCND2 translocation that relapsed with blastoid morphology and aggressive clinical behavior
    Kurita, Daisuke
    Takeuchi, Kengo
    Kobayashi, Sumiko
    Hojo, Atsuko
    Uchino, Yoshihito
    Sakagami, Masashi
    Ohtake, Shimon
    Takahashi, Hiromichi
    Miura, Katsuhiro
    Iriyama, Noriyoshi
    Sugitani, Masahiko
    Miyoshi, Hiroaki
    Hatta, Yoshihiro
    Ohshima, Koichi
    Takei, Masami
    VIRCHOWS ARCHIV, 2016, 469 (04) : 471 - 476
  • [49] A cyclin D1-negative mantle cell lymphoma with an IGL-CCND2 translocation that relapsed with blastoid morphology and aggressive clinical behavior
    Daisuke Kurita
    Kengo Takeuchi
    Sumiko Kobayashi
    Atsuko Hojo
    Yoshihito Uchino
    Masashi Sakagami
    Shimon Ohtake
    Hiromichi Takahashi
    Katsuhiro Miura
    Noriyoshi Iriyama
    Masahiko Sugitani
    Hiroaki Miyoshi
    Yoshihiro Hatta
    Koichi Ohshima
    Masami Takei
    Virchows Archiv, 2016, 469 : 471 - 476
  • [50] LRPAP1 autoantibodies in mantle cell lymphoma are associated with superior outcome
    Thurner, Lorenz
    Fadle, Natalie
    Bittenbring, Joerg Thomas
    Regitz, Evi
    Schuck, Rita
    Cetin, Onur
    Stuhr, Ariane
    Rixecker, Torben
    Murawski, Niels
    Poeschel, Viola
    Kaddu-Mulindwa, Dominic
    Preuss, Klaus-Dieter
    Stilgenbauer, Stephan
    Hermine, Olivier
    Kluin-Nelemans, Hanneke C.
    Hartmann, Sylvia
    Dreyling, Martin
    Pott, Christiane
    Bewarder, Moritz
    Hoster, Eva
    BLOOD, 2021, 137 (23) : 3251 - 3258
12345