Coexistence of BCL1/CCND1 and CMYC aberrations in blastoid mantle cell lymphoma: a rare finding associated with very poor outcome

被引：0
|
作者：
L. Michaux
I. Wlodarska
I. Theate
M. Stul
J.-M. Scheiff
V. Deneys
A. Ferrant
A. Hagemeijer
机构：
[1] Cliniques universitaires UCL St Luc,Department of Hematology, Clinical Biology and Pathology
[2] University of Leuven,Center for Human Genetics
来源：
Annals of Hematology | 2004年 / 83卷
关键词：
Mantle cell lymphoma; Blastoid; CMYC;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
A patient with mantle cell lymphoma (MCL) of the pleomorphic blastoid subtype is reported. The disease was clinically aggressive and refractory to chemotherapy, and the patient survived only 2 months. Cytogenetically, a t(11;19;14)(q13;q13;q32) was found. Fluorescent in situ hybridization (FISH) and molecular analyses demonstrated involvement of the BCL1/CCND1 locus in a three-way translocation. In addition, subclonal abnormalities of the region 8q24 manifested either as a t(8;22)(q24;q11)/CMYC rearrangement or trisomy 8 were identified. The pathogenetic impact of this very uncommon association of BCL1/CCND1 and CMYC rearrangements in MCL is discussed and the literature is reviewed.
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页码：578 / 583
页数：5
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