Plasma levels of interleukin-33 and soluble suppression of tumorigenicity 2 in patients with advanced pancreatic ductal adenocarcinoma undergoing systemic chemotherapy

被引：0
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作者：
Markus Kieler
Matthias Unseld
Johann Wojta
Alexandra Kaider
Daniela Bianconi
Svitlana Demyanets
Gerald W. Prager
机构：
[1] Medical University Vienna,Division of Oncology, Department of Medicine I, Comprehensive Cancer Center
[2] Medical University Vienna,Division of Cardiology, Department of Internal Medicine II
[3] Medical University of Vienna,Center for Medical Statistics, Informatics and Intelligent Systems
[4] Medical University of Vienna,Department of Laboratory Medicine
来源：
Medical Oncology | 2019年 / 36卷
关键词：
IL-33; sST2; Cytokines; Pancreatic ductal adenocarcinoma; Chronic inflammation;
D O I：
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摘要：
Interleukin-33 (IL-33) and its “decoy” receptor soluble ST2 (sST2) are involved in the development of chronic inflammation and cancer. We explored IL-33 and sST2 as a potential prognostic marker in patients with metastatic and locally advanced pancreatic ductal adenocarcinoma (PDAC). IL-33 and sST2 plasma levels were assessed in 20 patients with advanced PDAC before start of systemic chemotherapy and were analyzed in relation to clinical outcome. Kaplan Meier and multivariable Cox proportional hazards model analysis revealed a significant association between sST2 plasma levels and survival (HR 2.10, 95% CI 1.33–3.41, p = 0.002) and link high sST2 plasma levels to inferior survival in patients with advanced PDAC undergoing chemotherapy.
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