ALA- and ALA-ester-mediated Photodynamic Therapy of Human Glioma Spheroids

被引：0
作者：
Henry Hirschberg
Chung-Ho Sun
Bruce J. Tromberg
Steen J. Madsen
机构：
[1] Rikshospitalet,Department of Neurosurgery
[2] University of California,Beckman Laser Institute and Medical Clinic
[3] University of Nevada,Department of Health Physics
[4] University of Nevada,Las Vegas Cancer Institute
来源：
Journal of Neuro-Oncology | 2002年 / 57卷
关键词：
glioma; photodynamic therapy; ALA; ALA esters; spheroid;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The effects of photodynamic therapy (PDT) in human glioma spheroids incubated in 5-aminolevulinic acid (ALA), or ALA esters, are investigated. Spheroid survival and growth are monitored following PDT at representative drug concentrations, light doses, and dose rates. The primary finding of this study is that the response of human glioma spheroids to PDT with lipophilic ester derivatives, such as benzyl-ALA and hexyl-ALA, is equivalent to that observed with ALA, however, this equivalency is obtained for ester concentrations 10–20 times lower than the parent compound. The enhanced efficiency of the esters is likely due to their increased membrane penetrance. Potential clinical advantages of using lipophilic esters in PDT of gliomas are discussed.
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页码：1 / 7
页数：6
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