Prodigiosin induces apoptosis of B and T cells from B-cell chronic lymphocytic leukemia

被引：0

作者：

C Campàs

M Dalmau

B Montaner

M Barragán

B Bellosillo

D Colomer

G Pons

R Pérez-Tomás

J Gil

机构：

[1] Departament de Ciències Fisiològiques II,

[2] Unitat de Bioquímica,undefined

[3] Facultat de Medicina,undefined

[4] Universitat de Barcelona,undefined

[5] Laboratori de Citometria,undefined

[6] Campus de Bellvitge,undefined

[7] Universitat de Barcelona,undefined

[8] Departament de Biologia cel-lular i Anatomia Patològica,undefined

[9] Cancer Cell Biology Research Group,undefined

[10] Facultat de Medicina,undefined

[11] Universitat de Barcelona,undefined

[12] Unitat d'Hematopatologia,undefined

[13] Hospital Clínic,undefined

[14] IDIBAPS,undefined

来源：

Leukemia | 2003年 / 17卷

关键词：

apoptosis; B-CLL; caspases; chemotherapy;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

We have previously reported that prodigiosin (2-methyl-3-pentyl-6-methoxyprodigiosene) induces apoptosis in human hematopoietic cancer cell lines with no marked toxicity in nonmalignant cell lines. In this study, we demonstrate that prodigiosin induces apoptosis of B-cell chronic lymphocytic leukemia (B-CLL) cells (n=32 patients). The dose–response for the cytotoxic effect of prodigiosin was analyzed in cells from 12 patients showing an IC50 of 116±25 nM. Prodigiosin induced apoptosis of B-CLL cells through caspase activation. We also analyzed the cytotoxic effect of prodigiosin in T cells from B-CLL samples and no differences were observed with respect to leukemia cells. This is the first report showing that prodigiosin induces apoptosis in human primary cancer cells.

引用

页码：746 / 750

页数：4

共 129 条

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